{"id":"W3151030340","doi":"10.1085/jgp.202012701","title":"Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity","year":2021,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada); Simon Fraser University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Vetenskapsrådet; National Institutes of Health; Science for Life Laboratory; Mitacs; Rare Disease Foundation","keywords":"Sodium channel; Biophysics; Chemistry; Bilayer; NAV1; Cannabidiol; Membrane potential; Skeletal muscle; Membrane; Biochemistry; Cell biology; Biology; Sodium; Medicine; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008954995,0.0002626938,0.0002185073,0.000111721,0.0001992357,0.0001988911,0.0003624273,0.0003010497,0.001306843],"category_scores_gemma":[0.0001129186,0.0001361474,0.0003185029,0.00008077877,0.0002620147,0.0002625385,0.0002251682,0.0005039873,0.0002760768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004284363,"about_ca_system_score_gemma":0.0003134006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001550008,"about_ca_topic_score_gemma":0.002029567,"domain_scores_codex":[0.9999104,0.000008264338,0.00000580389,0.00001715238,0.00003177703,0.0000265642],"domain_scores_gemma":[0.9999685,0.000005896093,0.00001042706,0.0000038455,0.000003813362,0.000007560949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001267805,0.00002079908,0.00009675168,0.00002969833,0.000004373074,0.00002703514,0.00000723826,0.0001238208,0.9983607,0.0001697446,0.00002212894,0.001010896],"study_design_scores_gemma":[0.00003753783,0.0002329025,0.002284668,0.00000655657,0.00001760617,0.0001122034,0.00002240369,0.002475274,0.9933508,0.0001264927,0.001326845,0.000006631997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947278,0.0009017423,0.002191731,0.000142461,0.00002385985,0.00002423346,0.0001733752,0.00004923005,0.001765616],"genre_scores_gemma":[0.9937111,0.001055858,0.003038884,0.0000873772,0.000008513633,0.00003357212,0.0001424859,0.00001535781,0.001906875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001550008,"threshold_uncertainty_score":0.004371762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150549644958301,"score_gpt":0.2710005355825808,"score_spread":0.2594950391329978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}