{"id":"W3151214418","doi":"10.1007/s10600-021-03370-6","title":"Synthesis and Cytotoxic Activity of 5α-Pregnanolone Hydrazones","year":2021,"lang":"en","type":"article","venue":"Chemistry of Natural Compounds","topic":"Synthesis and Reactions of Organic Compounds","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Chicoutimi","funders":"","keywords":"Chemistry; Cytotoxic T cell; Pregnanolone; Stereochemistry; Biochemistry; In vitro; Neuroactive steroid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008070267,0.0002314387,0.0005239171,0.00003027395,0.00009893193,0.00002470148,0.0002717988,0.0002052458,0.0006290171],"category_scores_gemma":[0.0003351216,0.0002222618,0.0001898674,0.0001900084,0.0003000078,0.0001028851,0.0002070657,0.00028434,0.000001616885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005786756,"about_ca_system_score_gemma":0.0001019675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002275647,"about_ca_topic_score_gemma":0.000002934604,"domain_scores_codex":[0.9987839,0.00001599641,0.0003341279,0.0003695579,0.0002787003,0.0002176982],"domain_scores_gemma":[0.9983892,0.0005018917,0.0002667292,0.0005855806,0.000173026,0.00008350288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004599319,0.0002150225,0.0007822876,0.0007015077,0.0001461639,0.000012553,0.00003598554,6.371539e-7,0.992036,0.00001022499,0.0001303117,0.00588329],"study_design_scores_gemma":[0.0002907634,0.000005236557,0.001541657,0.0003096451,0.00008242988,0.000222105,0.0001677415,0.00008802724,0.9959054,0.00008350433,0.001079082,0.0002243821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839114,0.003337254,0.000003285226,0.0003054884,0.00008106748,0.0000209657,0.00003321494,0.00005015214,0.01225715],"genre_scores_gemma":[0.9977068,0.0002802323,0.0003063558,0.000004847908,0.00009093081,0.00000625456,0.00001282204,0.00002321296,0.001568596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01379533,"threshold_uncertainty_score":0.9063573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073004765724357,"score_gpt":0.2252529474411969,"score_spread":0.2145228997839533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}