{"id":"W3151331848","doi":"10.3171/case2078","title":"Adult isocitrate dehydrogenase–mutant brainstem glioma: illustrative case","year":2021,"lang":"en","type":"article","venue":"Journal of Neurosurgery Case Lessons","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University Health Network; University of Toronto","funders":"","keywords":"Isocitrate dehydrogenase; Brainstem; Glioma; Medicine; IDH1; Anaplastic astrocytoma; Pathology; Astrocytoma; Mutant; Oncology; Cancer research; Internal medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001581053,0.001310098,0.0006081208,0.001577231,0.001206185,0.0007198361,0.0008771318,0.003107506,0.001954167],"category_scores_gemma":[0.0009867775,0.0004668924,0.0004679566,0.001221603,0.001007912,0.001084183,0.0009275162,0.001715041,0.0007658661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001286691,"about_ca_system_score_gemma":0.0005325855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002174675,"about_ca_topic_score_gemma":0.004520338,"domain_scores_codex":[0.9997608,0.00002194311,0.00002762549,0.00005153296,0.00004649647,0.00009159789],"domain_scores_gemma":[0.9994959,0.0001067259,0.0001178298,0.00004826336,0.00002658208,0.0002047783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00002354087,0.00002857421,0.00309829,0.00002854004,0.000006041098,0.993452,0.0001216937,0.0001453314,0.0006790843,0.000352733,0.0003118586,0.001752405],"study_design_scores_gemma":[0.00000768392,0.00003368364,0.003914177,0.00001039897,0.000006160916,0.9945853,0.00009813568,0.0002460232,0.0002017086,0.00028795,0.0006024556,0.000006322809],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690083,0.006008314,0.004656923,0.003495931,0.000289389,0.0001745193,0.0003331021,0.0002848948,0.01574875],"genre_scores_gemma":[0.995073,0.001083279,0.001633521,0.0005680102,0.0003411609,0.0000191852,0.00007260127,0.00001170825,0.001197483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003107506,"threshold_uncertainty_score":0.009335577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03946471497492138,"score_gpt":0.3061836701926552,"score_spread":0.2667189552177338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}