{"id":"W3151414537","doi":"10.1016/j.eururo.2021.03.001","title":"Treatment and Patient Selection for Patients with Metastatic Castration-resistant Prostate After Progression on Docetaxel and Abiraterone/Enzalutamide: When to Play Your CARD and When to Do Your PARP","year":2021,"lang":"en","type":"editorial","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Enzalutamide; Docetaxel; Cabazitaxel; Medicine; Prostate cancer; Oncology; PARP inhibitor; Internal medicine; Chemotherapy; Abiraterone; Poly ADP ribose polymerase; Androgen receptor; Olaparib; Pharmacology; Cancer research; Cancer; Androgen deprivation therapy; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009528217,0.002662823,0.003878733,0.002157276,0.00176657,0.004494199,0.002772029,0.01341854,0.006718453],"category_scores_gemma":[0.031279,0.001256549,0.002855274,0.001304009,0.001390064,0.002442873,0.0008035803,0.02335467,0.003525405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003324184,"about_ca_system_score_gemma":0.003704038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002663513,"about_ca_topic_score_gemma":0.009847149,"domain_scores_codex":[0.995923,0.001298097,0.0006740856,0.0004520162,0.001396011,0.0002566268],"domain_scores_gemma":[0.9753431,0.01400706,0.001405889,0.0004456617,0.005473495,0.003324693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001314165,0.00002689724,0.0001072814,0.0003011835,0.00006236969,0.0001624326,0.00001041013,0.00005785542,0.00003849928,0.00018787,0.986987,0.01192677],"study_design_scores_gemma":[0.000714057,0.0001899972,0.002431222,0.001354712,0.0005544139,0.0009748662,0.00008356594,0.0006907255,0.0001155172,0.001342219,0.9914926,0.00005613896],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0001278655,0.01298342,0.0002172311,0.08397999,0.9008467,0.0000346544,0.00008511313,0.00004766653,0.001677364],"genre_scores_gemma":[0.0009098891,0.007067535,0.000211331,0.03289708,0.9551854,0.00003709511,0.00005313344,0.00002303199,0.003615513],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.01341854,"threshold_uncertainty_score":0.05039066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806863749920977,"score_gpt":0.303282293205035,"score_spread":0.2852136557058252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}