{"id":"W3151505747","doi":"10.3390/biom11040504","title":"Fitness Shifts the Balance of BDNF and IL-6 from Inflammation to Repair among People with Progressive Multiple Sclerosis","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Research and Development Corporation of Newfoundland and Labrador; Canada Excellence Research Chairs, Government of Canada; Canada Foundation for Innovation","keywords":"Inflammation; Balance (ability); Neurotrophic factors; Internal medicine; Neurodegeneration; Brain-derived neurotrophic factor; Medicine; Multiple sclerosis; Endocrinology; Interleukin; Systemic inflammation; Physical therapy; Immunology; Cytokine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382164,0.0001456334,0.0002923707,0.00005654038,0.000121285,0.00003418346,0.00008991041,0.00005017952,0.00002550918],"category_scores_gemma":[0.001111732,0.00009084897,0.0000583821,0.000401846,0.0003076963,0.00007209007,0.0001927022,0.00009160225,0.000004925585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002871957,"about_ca_system_score_gemma":0.00007270737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005413696,"about_ca_topic_score_gemma":0.00143226,"domain_scores_codex":[0.9986908,0.00009447629,0.0002183896,0.0003371685,0.0004335754,0.0002255977],"domain_scores_gemma":[0.9986863,0.0003179062,0.00009743253,0.0004030096,0.0003751188,0.0001202599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002909196,0.00009206145,0.6624063,0.000153346,0.0001998855,0.00003510024,0.0026503,0.000008303004,0.3278644,0.00003693399,0.0004515468,0.005810908],"study_design_scores_gemma":[0.0009373182,0.000127358,0.8229647,0.0005113225,0.00004239555,0.000002813644,0.001136763,0.0006551745,0.1733573,0.000006241093,0.0001678572,0.00009084342],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952129,0.001020516,0.0003084973,0.00252049,0.00002792171,0.0006759366,0.00008365879,0.00005734918,0.00009272391],"genre_scores_gemma":[0.9948327,0.0002093445,0.004526384,0.00007119826,0.00007882599,0.000174415,0.00004537214,0.00001878357,0.00004296362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1605583,"threshold_uncertainty_score":0.3704714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02796431589587198,"score_gpt":0.2712669237338526,"score_spread":0.2433026078379807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}