{"id":"W3151505747","doi":"10.3390/biom11040504","title":"Fitness Shifts the Balance of BDNF and IL-6 from Inflammation to Repair among People with Progressive Multiple Sclerosis","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Research and Development Corporation of Newfoundland and Labrador; Canada Excellence Research Chairs, Government of Canada; Canada Foundation for Innovation","keywords":"Inflammation; Balance (ability); Neurotrophic factors; Internal medicine; Neurodegeneration; Brain-derived neurotrophic factor; Medicine; Multiple sclerosis; Endocrinology; Interleukin; Systemic inflammation; Physical therapy; Immunology; Cytokine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152073,0.0002717636,0.0003174661,0.0004676426,0.0003010474,0.0003227311,0.0001099508,0.0004575531,0.0009268214],"category_scores_gemma":[0.0005849269,0.0001259783,0.0002352636,0.0003571102,0.0001646178,0.0002170935,0.0002575652,0.0002887424,0.0001981377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001132564,"about_ca_system_score_gemma":0.00007073519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001793561,"about_ca_topic_score_gemma":0.002322316,"domain_scores_codex":[0.9998871,0.00002121837,0.000013574,0.00003364876,0.00002069927,0.0000236909],"domain_scores_gemma":[0.9998385,0.00002229654,0.00006332949,0.00001058772,0.00002165786,0.00004359035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001122887,0.0002460261,0.9750992,0.00007152179,0.000137865,0.0002195145,0.0005539722,0.0000564457,0.009520445,0.00001982856,0.0001040512,0.01284815],"study_design_scores_gemma":[0.00000561508,0.0002902124,0.9992868,0.000004215238,0.00002453916,0.00008776446,0.00007656545,0.00003429932,0.0001191401,0.00001657503,0.00005252184,0.000001786803],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995381,0.0002170604,0.00003633877,0.00002331622,0.00000373393,0.000003140206,0.00003428456,0.000002474139,0.0001416991],"genre_scores_gemma":[0.9996338,0.00008078497,0.00003530689,0.00002365862,0.00000503722,0.000003892647,0.00004716619,6.569243e-7,0.000169704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793561,"threshold_uncertainty_score":0.003566265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02796431589587198,"score_gpt":0.2712669237338526,"score_spread":0.2433026078379807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}