{"id":"W3151522019","doi":"10.1371/journal.pgen.1009511","title":"The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Institutes of Health Research; Fondation CHU de Québec","keywords":"Argonaute; Biology; Gene silencing; microRNA; Cell biology; Small GTPase; RNA interference; Caenorhabditis elegans; Regulation of gene expression; Translation (biology); GTPase; Genetics; Gene; Messenger RNA; RNA; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497867,0.0005799875,0.0002636025,0.0005053865,0.0004158516,0.0003873112,0.0005201966,0.0004286644,0.00095998],"category_scores_gemma":[0.0002294069,0.000357854,0.0002575814,0.0001218395,0.000529797,0.0002006991,0.0004906892,0.0005158893,0.0004921106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008095957,"about_ca_system_score_gemma":0.0005104488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002931733,"about_ca_topic_score_gemma":0.004660798,"domain_scores_codex":[0.9997848,0.00002664294,0.00002234931,0.00006053426,0.00005672703,0.00004898148],"domain_scores_gemma":[0.9996502,0.0000648191,0.00009985142,0.00003714007,0.00004067532,0.0001072979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003546142,0.000005671237,0.00009006773,0.00001168405,0.000001289377,0.00005176675,0.000007220246,0.00008132,0.9993399,0.0001015777,0.00001412531,0.0002598552],"study_design_scores_gemma":[0.00002317095,0.00008929882,0.007825688,0.00001085839,0.00001533844,0.0002721356,0.00003818368,0.005159387,0.9849418,0.0001090051,0.001499281,0.00001572596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967216,0.0003143013,0.001445855,0.00005752264,0.00001422539,0.00001112104,0.0001425264,0.0001435487,0.001149332],"genre_scores_gemma":[0.9961686,0.0001427547,0.001672977,0.00002751106,0.000002522625,0.00002806126,0.000128383,0.00007037493,0.001758902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002931733,"threshold_uncertainty_score":0.005874038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620077059398762,"score_gpt":0.2529490971670237,"score_spread":0.2367483265730361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}