{"id":"W3151543485","doi":"10.1158/2159-8290.cd-20-1677","title":"Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; European Hematology Association; National Heart, Lung, and Blood Institute; Stand Up To Cancer; Doris Duke Charitable Foundation","keywords":"Persistence (discontinuity); Profiling (computer programming); Cell; Computational biology; Term (time); Biology; Cell biology; Genetics; Computer science; Physics; Engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001854822,0.0001288128,0.0002508077,0.0002819596,0.0001808438,0.0005069867,0.0001149424,0.0002215697,0.001201348],"category_scores_gemma":[0.0002272662,0.00008249204,0.0001770611,0.0001849263,0.0001545699,0.0001508688,0.0001719695,0.0004093932,0.0004349345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001803065,"about_ca_system_score_gemma":0.0001455959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003410222,"about_ca_topic_score_gemma":0.0004733814,"domain_scores_codex":[0.9998488,0.00001743701,0.000009368147,0.00004263759,0.00004315163,0.00003848016],"domain_scores_gemma":[0.9998559,0.00003325856,0.00003280857,0.00001725379,0.00003592296,0.00002498497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002265492,0.00002658961,0.01254491,0.00003062355,0.00001530737,0.00004028016,0.00007436275,0.0003419924,0.979777,0.00006592883,0.00009798459,0.006758365],"study_design_scores_gemma":[0.00002937425,0.001289326,0.2787179,0.0000172144,0.0001146795,0.0009335559,0.0007266943,0.008333018,0.704371,0.0004976145,0.004945559,0.00002410118],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940791,0.0005411085,0.004032799,0.00003578162,0.000007026077,0.00002322451,0.0007371079,0.00005555539,0.0004883571],"genre_scores_gemma":[0.9968091,0.0001517128,0.001404413,0.00005080724,0.000007691419,0.00003290709,0.0009515981,0.00001885443,0.0005728282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001201348,"threshold_uncertainty_score":0.004018962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07317010384896924,"score_gpt":0.3271938155873689,"score_spread":0.2540237117383997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}