{"id":"W3151546070","doi":"10.1016/j.jcmgh.2021.03.008","title":"Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett’s Esophagus","year":2021,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Health and Medical Research Council; University of Melbourne; Department of Health and Human Services, State Government of Victoria; Medical Research Council; Marshfield Clinic Research Foundation; Victorian Cancer Agency; U.S. Department of Health and Human Services","keywords":"Esophagus; Barrett's esophagus; Carcinogenesis; Medicine; Internal medicine; Gastroenterology; Adenocarcinoma; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002574282,0.0005704524,0.0003430531,0.0005188195,0.000213982,0.0003286147,0.0003545962,0.0004341293,0.002160658],"category_scores_gemma":[0.0001427447,0.000281094,0.0003921786,0.0001797884,0.0004048017,0.0002342515,0.0002633194,0.0008933783,0.0004723645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003683304,"about_ca_system_score_gemma":0.0003012857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004491414,"about_ca_topic_score_gemma":0.0008271963,"domain_scores_codex":[0.9997589,0.00004671425,0.00003320051,0.00004617574,0.00006714034,0.00004784668],"domain_scores_gemma":[0.9996965,0.0000525768,0.00009678897,0.00003844305,0.00002264958,0.00009305744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000217235,0.00007727174,0.0001141441,0.00003119409,0.000006351089,0.00003289688,0.000008194142,0.00004350301,0.9990587,0.00004142509,0.00001929507,0.0003499254],"study_design_scores_gemma":[0.00003827824,0.000730861,0.001772068,0.000006783156,0.00002546486,0.0001497874,0.00002967381,0.0006933605,0.9952484,0.00003049922,0.001270604,0.00000410013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995116,0.0008650582,0.002061079,0.0001517896,0.0000532514,0.00005682417,0.0004745286,0.0001219282,0.001099444],"genre_scores_gemma":[0.9879827,0.001028858,0.003491845,0.00009254192,0.00001530882,0.0001214438,0.0008838534,0.00006323594,0.006320198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002160658,"threshold_uncertainty_score":0.007228136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01237585185769242,"score_gpt":0.2609518154270584,"score_spread":0.248575963569366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}