{"id":"W3151612263","doi":"10.1021/ol802870c","title":"Total Synthesis of FR901483","year":2009,"lang":"en","type":"article","venue":"Organic Letters","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Cyclopropane; Imine; Natural product; Total synthesis; Sequence (biology); Functional group; Combinatorial chemistry; In situ; Group (periodic table); Acceptor; Stereochemistry; Organic chemistry; Ring (chemistry); Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001080699,0.0004722754,0.0003646858,0.0002125705,0.0002078452,0.0001718958,0.0003340603,0.0002225988,0.004642698],"category_scores_gemma":[0.0001171739,0.0001163364,0.00026703,0.0002930676,0.0001188614,0.0001975755,0.0002558898,0.0004344027,0.002671456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003128848,"about_ca_system_score_gemma":0.0004445646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267319,"about_ca_topic_score_gemma":0.001696291,"domain_scores_codex":[0.9999175,0.000006240835,0.000005986055,0.00001703734,0.00002041772,0.00003286556],"domain_scores_gemma":[0.9999731,0.000002568744,0.000004801541,0.000004679826,0.000007333683,0.000007555692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009959473,0.00002693998,0.0000598653,0.000139961,0.00001818766,0.0002211433,0.0000563223,0.0004687189,0.9845161,0.0011554,0.0007880749,0.01244958],"study_design_scores_gemma":[0.00005446887,0.0004147023,0.0008742273,0.00001035045,0.00003362194,0.000312463,0.00002466082,0.0008438682,0.9749658,0.0002565793,0.02218897,0.0000203132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8912466,0.002485647,0.05212925,0.0003412093,0.0002217097,0.000535956,0.006818574,0.002309678,0.04391128],"genre_scores_gemma":[0.9654821,0.001728355,0.01454248,0.0001486772,0.00001683468,0.0001784085,0.004269166,0.0002369038,0.01339712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004642698,"threshold_uncertainty_score":0.01553136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003252546146868463,"score_gpt":0.1949038914566696,"score_spread":0.1916513453098011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}