{"id":"W3151612263","doi":"10.1021/ol802870c","title":"Total Synthesis of FR901483","year":2009,"lang":"en","type":"article","venue":"Organic Letters","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Cyclopropane; Imine; Natural product; Total synthesis; Sequence (biology); Functional group; Combinatorial chemistry; In situ; Group (periodic table); Acceptor; Stereochemistry; Organic chemistry; Ring (chemistry); Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005509311,0.00007309348,0.00008423105,0.00001822507,0.00001822369,0.000004391338,0.00009948829,0.00004593215,0.00008722497],"category_scores_gemma":[0.00008393476,0.00006367633,0.00004569833,0.00005984428,0.00002138777,0.000001657632,0.00003220293,0.00004355983,0.000009517375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004697041,"about_ca_system_score_gemma":0.0000116487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005615324,"about_ca_topic_score_gemma":0.000001387136,"domain_scores_codex":[0.9995459,0.00001447359,0.00009279417,0.0001643212,0.00006467919,0.0001178491],"domain_scores_gemma":[0.9996905,0.000004682928,0.00003844397,0.0002197144,0.00001841372,0.00002825207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000158158,0.00001558335,0.0002056306,0.000004665733,0.00001287788,0.000001441403,0.000005485085,0.000001554248,0.9863369,0.00002273172,0.006581695,0.006795592],"study_design_scores_gemma":[0.0001011233,0.00007332987,0.01101474,0.000003747743,0.00001002663,0.00001298836,0.000003881019,0.000001830781,0.9863324,0.000009920735,0.002349213,0.00008678568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939299,0.0001449612,0.00004088047,0.005256468,0.00007949342,0.00004535156,0.00000247861,0.000007016859,0.0004934436],"genre_scores_gemma":[0.9979042,0.00003103985,0.0002542444,0.001406328,0.0002051904,6.155941e-7,0.00001000766,0.000007272294,0.0001810954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0108091,"threshold_uncertainty_score":0.2596645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003252546146868463,"score_gpt":0.1949038914566696,"score_spread":0.1916513453098011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}