{"id":"W3151668984","doi":"10.3389/fcell.2021.668171","title":"Telomere Replication: Solving Multiple End Replication Problems","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Telomere; Biology; DNA replication; Telomerase; Control of chromosome duplication; Genome instability; Minichromosome maintenance; Semiconservative replication; Origin recognition complex; Genetics; Pre-replication complex; Licensing factor; Eukaryotic DNA replication; DNA; Cell biology; Gene; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004194801,0.0004642734,0.001736567,0.000376408,0.0001301631,0.00002693225,0.0002058789,0.0006078474,0.00008457622],"category_scores_gemma":[0.0002517726,0.0003950049,0.0001712473,0.0005417344,0.0002063253,0.00006227141,0.00018767,0.0004985585,0.00003348785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003444846,"about_ca_system_score_gemma":0.0006224714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004483417,"about_ca_topic_score_gemma":0.00001610252,"domain_scores_codex":[0.9968572,0.0001442872,0.0009397481,0.001475745,0.000131796,0.0004511825],"domain_scores_gemma":[0.9985272,0.0001401714,0.0003267147,0.000762233,0.00006738738,0.0001762388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001279434,0.0001083864,0.01376394,0.005175035,0.00008484594,0.00003003134,0.0002333443,3.652408e-8,0.0001370789,0.00002248244,0.006358563,0.9740735],"study_design_scores_gemma":[0.0005387921,0.00006107314,0.0004985766,0.003292188,0.0001246404,0.0003313535,0.0002953665,0.00001090354,0.0002205129,0.00004695605,0.9941341,0.0004455001],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003658228,0.9944583,0.0003162187,0.00007728187,0.0005891252,0.001157103,0.00003794621,0.0000662278,0.002931988],"genre_scores_gemma":[0.0003989644,0.9669402,0.02831117,0.0001659071,0.0001195556,0.0003034416,0.001977184,0.0000471276,0.001736415],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9877756,"threshold_uncertainty_score":0.9998502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04163744426217308,"score_gpt":0.2998155336396253,"score_spread":0.2581780893774522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}