{"id":"W3151668984","doi":"10.3389/fcell.2021.668171","title":"Telomere Replication: Solving Multiple End Replication Problems","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Telomere; Biology; DNA replication; Telomerase; Control of chromosome duplication; Genome instability; Minichromosome maintenance; Semiconservative replication; Origin recognition complex; Genetics; Pre-replication complex; Licensing factor; Eukaryotic DNA replication; DNA; Cell biology; Gene; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002312943,0.00109711,0.001266928,0.001101937,0.001274991,0.002162738,0.001842799,0.003082221,0.005057171],"category_scores_gemma":[0.003585519,0.0006296968,0.00109866,0.001324474,0.00157576,0.006434595,0.002643508,0.00411888,0.004469906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009956952,"about_ca_system_score_gemma":0.001525215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009308188,"about_ca_topic_score_gemma":0.0005932983,"domain_scores_codex":[0.9986814,0.000221041,0.0000865584,0.0003946707,0.0004754501,0.0001408509],"domain_scores_gemma":[0.9983612,0.0005133708,0.0001905928,0.0002580011,0.000506055,0.0001708821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003817645,0.000160422,0.001494528,0.006244452,0.0001676048,0.0007420836,0.001056429,0.01009533,0.03638986,0.1294329,0.05101635,0.7628183],"study_design_scores_gemma":[0.0001169486,0.0004674334,0.0008080307,0.001119218,0.0001519886,0.002611287,0.000567526,0.01367852,0.02980527,0.2583737,0.6921028,0.0001973033],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.021709,0.5665271,0.3455558,0.02895524,0.01105958,0.000168089,0.0005202148,0.00201085,0.02349424],"genre_scores_gemma":[0.1614716,0.3929712,0.3570504,0.006476232,0.01603527,0.0002668902,0.001984208,0.0007348924,0.06300934],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005057171,"threshold_uncertainty_score":0.01691794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04163744426217308,"score_gpt":0.2998155336396253,"score_spread":0.2581780893774522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}