{"id":"W3151771386","doi":"10.3390/cancers13071588","title":"Increased Pathway Complexity Is a Prognostic Biomarker in Metastatic Castration-Resistant Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Kom op tegen Kanker; Stichting Tegen Kanker; Cancerfonden; Svenska Forskningsrådet Formas; Familjen Erling-Perssons Stiftelse","keywords":"Prostate cancer; Androgen receptor; Oncology; Medicine; Proportional hazards model; Internal medicine; Biomarker; Gene; Overall survival; Cancer research; Bioinformatics; Biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004556446,0.0002452385,0.0004122112,0.0007589434,0.0002143256,0.0006411273,0.0002157782,0.0002239822,0.001446138],"category_scores_gemma":[0.001461862,0.0001251266,0.0004328056,0.0009890646,0.0002320893,0.0002992518,0.0005923462,0.0003887133,0.0001297754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002599933,"about_ca_system_score_gemma":0.0003646919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001346687,"about_ca_topic_score_gemma":0.002095087,"domain_scores_codex":[0.9997256,0.00006662592,0.00002437181,0.00007199448,0.00007233252,0.00003895852],"domain_scores_gemma":[0.9989511,0.0002574178,0.0004785679,0.00007650768,0.00006661375,0.0001697972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00162985,0.0000388968,0.9820272,0.00006920423,0.0002940589,0.0001157952,0.00004275316,0.001043391,0.005987819,0.00005570758,0.0001481573,0.008547114],"study_design_scores_gemma":[0.00001582499,0.0002475858,0.9959293,0.000008273926,0.0001259318,0.0005218009,0.00004537607,0.001866683,0.0006197979,0.0002155254,0.0003957496,0.000008312047],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981383,0.0008296024,0.0002900403,0.00004211837,0.000002950875,0.000008551832,0.000438932,0.00001259235,0.000236946],"genre_scores_gemma":[0.9991729,0.0001580138,0.0001641492,0.00000875108,0.000004923901,0.000004523637,0.0004121389,0.000002213012,0.00007240078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001446138,"threshold_uncertainty_score":0.004837751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08999475463178652,"score_gpt":0.3590939879496954,"score_spread":0.2690992333179089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}