{"id":"W3151863758","doi":"10.1021/acsptsci.1c00010","title":"Selective Targeting of Vascular Endothelial YAP Activity Blocks EndMT and Ameliorates Unilateral Ureteral Obstruction-Induced Kidney Fibrosis","year":2021,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Department of Science and Technology of Sichuan Province; National Natural Science Foundation of China","keywords":"Fibrosis; Angiogenesis; Kidney; Medicine; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003367521,0.0001521133,0.0001681699,0.00007072391,0.0002993359,0.00002560441,0.0001622365,0.0001202522,0.00005741668],"category_scores_gemma":[0.00008949658,0.0001545256,0.00007545347,0.0003616163,0.0004022388,0.00003096396,0.00005273351,0.0001586532,0.000001018891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000157205,"about_ca_system_score_gemma":0.0006238883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002672073,"about_ca_topic_score_gemma":0.000004592813,"domain_scores_codex":[0.9986252,0.0001265445,0.000199376,0.0005031569,0.0002469556,0.0002988374],"domain_scores_gemma":[0.999293,0.0000550164,0.00009191014,0.0001018867,0.0003051608,0.0001530643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007439726,0.00004774833,0.004750846,0.00001208119,0.00006432248,0.000002862694,0.0002240085,0.0003042511,0.9936646,0.00003106446,0.00002442213,0.000799451],"study_design_scores_gemma":[0.0006918184,0.0001190481,0.008857137,0.000008529405,0.00004558313,0.00001947345,0.00002061287,0.0005581143,0.9886556,0.0001193208,0.0007442144,0.0001605888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985319,0.0002036915,0.0003780131,0.000265845,0.0002777626,0.0001160802,0.0000780969,0.00001263052,0.0001360164],"genre_scores_gemma":[0.997873,0.00005232809,0.001553835,0.0002240893,0.0001833364,0.00001298927,0.00005648023,0.000009767559,0.00003413721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005008984,"threshold_uncertainty_score":0.6301371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053155751069465,"score_gpt":0.2703130712204616,"score_spread":0.2597815137097669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}