{"id":"W3152264517","doi":"10.1016/j.provac.2011.10.002","title":"Non-animal replacement methods for human vaccine potency testing: state of the science and future directions","year":2011,"lang":"en","type":"article","venue":"Procedia in Vaccinology","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"National Institute of Environmental Health Sciences; National Institutes of Health","keywords":"Potency; Medicine; Tetanus; Poliomyelitis; Diphtheria; Vaccination; Rabies; Virology; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007364093,0.0000945348,0.0001382136,0.00008162325,0.0001467674,0.000007551154,0.0002645558,0.00008169177,0.00001090099],"category_scores_gemma":[0.000573049,0.00006871772,0.00002641145,0.00029759,0.0001073802,0.000005300344,0.0002334308,0.00009658586,2.85774e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001649,"about_ca_system_score_gemma":0.0001734145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009106229,"about_ca_topic_score_gemma":0.0001090783,"domain_scores_codex":[0.9990686,0.00003512382,0.0002118828,0.0003304207,0.00006773826,0.0002862732],"domain_scores_gemma":[0.9992236,0.00002281244,0.00008846069,0.0002477946,0.000369311,0.00004795531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002209845,0.00005729325,0.02483166,0.00003742999,0.000009801809,1.508693e-7,0.0002279115,1.482999e-7,0.9246535,0.0001844247,0.0000343803,0.04974234],"study_design_scores_gemma":[0.0007993444,0.001145598,0.3795433,0.0000070273,0.00001066946,0.00001522746,0.00005108571,0.00008954393,0.6100481,0.001235593,0.006940489,0.0001139531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975555,0.0004471335,0.0002194228,0.00017603,0.0002214306,0.0004728379,0.000005953512,0.000004781275,0.0008969309],"genre_scores_gemma":[0.99016,0.0001789236,0.009296367,0.00003521621,0.000131295,0.0001012235,0.000002359623,0.00001080541,0.00008384893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3547117,"threshold_uncertainty_score":0.2802227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0401151437495312,"score_gpt":0.3382865954943072,"score_spread":0.2981714517447761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}