{"id":"W3152524207","doi":"10.1055/a-1384-3715","title":"Factor XI as a Target for New Anticoagulants","year":2021,"lang":"en","type":"review","venue":"Hämostaseologie","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research; McMaster University; Heart and Stroke Foundation of Canada","keywords":"Medicine; Thrombosis; Heparin; Coagulation; Antithrombin; Anticoagulant; Discovery and development of direct thrombin inhibitors; Vitamin k; Intensive care medicine; Clotting factor; Factor X; Thrombin; Pharmacology; Surgery; Internal medicine; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005791594,0.0007549832,0.001093961,0.001787719,0.000198682,0.001085983,0.000583224,0.0009477653,0.003873617],"category_scores_gemma":[0.0005873608,0.0001664459,0.0004492208,0.001552052,0.0003740403,0.001337693,0.0005074131,0.001762029,0.001558287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005881066,"about_ca_system_score_gemma":0.001038662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007715072,"about_ca_topic_score_gemma":0.001142543,"domain_scores_codex":[0.9997638,0.00004269406,0.00003225866,0.00003560975,0.00010322,0.00002242228],"domain_scores_gemma":[0.9997988,0.00009437869,0.00003015173,0.000005645848,0.00005275557,0.00001816474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008107194,0.00005626931,0.0001843531,0.02020457,0.0001324943,0.0002810771,0.00007026806,0.0003042236,0.002268802,0.008092294,0.04428933,0.9240353],"study_design_scores_gemma":[0.00002238572,0.00007795909,0.0004830599,0.004315721,0.0001124484,0.001304722,0.0000404286,0.00007118355,0.0003705282,0.002343797,0.9908463,0.00001145199],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005189872,0.9990404,0.00005189699,0.0002300723,0.0001695716,0.000001583447,0.000006144636,0.000003582142,0.0004448611],"genre_scores_gemma":[0.0004720871,0.9986621,0.00008845663,0.0001657278,0.0001937794,0.000002774256,0.00001496143,7.67003e-7,0.0003992644],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003873617,"threshold_uncertainty_score":0.01295853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1905520075110753,"score_gpt":0.4263712599541173,"score_spread":0.235819252443042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}