{"id":"W3152536211","doi":"10.3390/biom11040581","title":"Use of Gene Therapy in Retinal Ganglion Cell Neuroprotection: Current Concepts and Future Directions","year":2021,"lang":"en","type":"review","venue":"Biomolecules","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Neuroprotection; Retinal ganglion cell; Neuroscience; Genetic enhancement; Retinal; Biology; Medicine; Retina; Gene; Ophthalmology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006936162,0.0002581555,0.0004449963,0.0001159004,0.00004124738,0.00003074502,0.00009057233,0.0002202755,0.000011837],"category_scores_gemma":[0.00002232607,0.0002232352,0.0001855873,0.0002789236,0.0001005703,0.000003415407,0.00006035103,0.0001342138,0.000001356161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001034413,"about_ca_system_score_gemma":0.0001472967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001712185,"about_ca_topic_score_gemma":0.00001004765,"domain_scores_codex":[0.9988161,0.0001945193,0.0003182907,0.0004157442,0.0001043601,0.0001510008],"domain_scores_gemma":[0.9994827,0.00001143916,0.0001753779,0.0002135149,0.00007059846,0.00004640375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000198732,0.00008827303,0.00004063998,0.0009419274,0.00003218014,0.00001172641,0.00002554959,1.274364e-7,0.003787915,0.00001472139,0.000377876,0.9946592],"study_design_scores_gemma":[0.0001735444,0.0001230762,0.00007135233,0.0005659077,0.00003438631,0.00003346496,0.00002205846,3.790039e-7,0.005368621,0.000001632244,0.9933773,0.0002282245],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002942952,0.9961513,0.00005289434,0.00002283821,0.0003515311,0.0003508844,0.00002668274,0.000006805224,0.00009406923],"genre_scores_gemma":[0.00009513772,0.9987836,0.0003326745,0.00001331284,0.0002289689,0.00005333555,0.0003786364,0.00002856004,0.00008570065],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.994431,"threshold_uncertainty_score":0.9103268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03437640934887609,"score_gpt":0.3133565070566572,"score_spread":0.2789800977077811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}