{"id":"W3152536211","doi":"10.3390/biom11040581","title":"Use of Gene Therapy in Retinal Ganglion Cell Neuroprotection: Current Concepts and Future Directions","year":2021,"lang":"en","type":"review","venue":"Biomolecules","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Neuroprotection; Retinal ganglion cell; Neuroscience; Genetic enhancement; Retinal; Biology; Medicine; Retina; Gene; Ophthalmology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005378093,0.0009292011,0.003981215,0.01597244,0.0004698051,0.002798692,0.001521071,0.001820077,0.005570451],"category_scores_gemma":[0.009171386,0.0004609973,0.002338967,0.0166066,0.0007769394,0.002869128,0.0009460881,0.0007947774,0.0009892969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001968069,"about_ca_system_score_gemma":0.006154231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001821337,"about_ca_topic_score_gemma":0.004842943,"domain_scores_codex":[0.9976048,0.0004988295,0.001121472,0.0001774848,0.0005072089,0.0000901577],"domain_scores_gemma":[0.9863809,0.009409207,0.002371657,0.0001802114,0.001433291,0.0002247332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002825577,0.00003996089,0.001029404,0.6967704,0.00127929,0.0005412038,0.0002773958,0.0001250598,0.001175563,0.001336353,0.00609475,0.291048],"study_design_scores_gemma":[0.0001789931,0.0004833908,0.006632832,0.6947243,0.01461316,0.002226256,0.0007826604,0.0001495308,0.001224448,0.002605982,0.2763137,0.00006478339],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004897251,0.9984074,0.00008892254,0.0004171776,0.00009984186,0.00002587113,0.0001313684,0.000004898755,0.0003348635],"genre_scores_gemma":[0.002523603,0.9959427,0.0004654066,0.0005699305,0.0001322339,0.0000574869,0.0001702297,0.000004115036,0.0001344083],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01597244,"threshold_uncertainty_score":0.02844244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03437640934887609,"score_gpt":0.3133565070566572,"score_spread":0.2789800977077811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}