{"id":"W3152675979","doi":"10.1111/bph.15498","title":"The T‐type calcium channel antagonist, Z944, reduces spinal excitability and pain hypersensitivity","year":2021,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of British Columbia; Hospital for Sick Children; Canada's Michael Smith Genome Sciences Centre; Carleton University; University of Toronto; University of Calgary","funders":"Institute of Neurosciences, Mental Health and Addiction; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Antagonist; Calcium channel; Medicine; Voltage-dependent calcium channel; T-type calcium channel; Pharmacology; Anesthesia; Calcium; Neuroscience; Internal medicine; Receptor; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008506642,0.0004315939,0.0005382351,0.0003300489,0.0002350374,0.0002880734,0.0005130667,0.0005309415,0.003017106],"category_scores_gemma":[0.0003051737,0.0001933684,0.0003055551,0.0001842012,0.0003578237,0.0003124516,0.0001599861,0.0007579091,0.0004864186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003108099,"about_ca_system_score_gemma":0.0004826977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001094493,"about_ca_topic_score_gemma":0.001892007,"domain_scores_codex":[0.9999079,0.0000109529,0.00001075197,0.00001384872,0.00002407526,0.00003253266],"domain_scores_gemma":[0.9998646,0.00002194886,0.00005028463,0.000009008671,0.00002080605,0.00003329499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007566442,0.00006705605,0.0001444964,0.00008215919,0.00001352513,0.00002676854,0.000006985595,0.00009371195,0.9962676,0.00004674277,0.00007302444,0.002421332],"study_design_scores_gemma":[0.0005853369,0.004863482,0.008624544,0.00002201293,0.0001280438,0.0005648747,0.00005358345,0.001265038,0.9821429,0.0001396612,0.001592875,0.00001768853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931744,0.001991225,0.002153393,0.000261692,0.00004329842,0.00007780718,0.0004915821,0.0002334535,0.001573079],"genre_scores_gemma":[0.9927625,0.002407907,0.001930777,0.0001379722,0.00003579805,0.00009856436,0.0004180349,0.00004033255,0.002168077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003017106,"threshold_uncertainty_score":0.01009321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02857146470518697,"score_gpt":0.3293449298913069,"score_spread":0.3007734651861199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}