{"id":"W3152824761","doi":"10.1007/s00401-021-02302-6","title":"Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Universitätsklinikum Heidelberg; Friedberg Charitable Foundation; Medical Research Council; Deutschen Konsortium für Translationale Krebsforschung; University College London Hospitals NHS Foundation Trust; Deutsche Krebshilfe; Making Headway Foundation; National Institute for Health and Care Research; Else Kröner-Fresenius-Stiftung; Deutsche Forschungsgemeinschaft","keywords":"CDKN2A; PTEN; Biology; Primitive neuroectodermal tumor; Pathology; Phenotype; Histology; DNA methylation; Cancer research; Immunohistochemistry; Cancer; Genetics; Medicine; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006605704,0.0001708276,0.0003014554,0.00004617901,0.00007130345,0.00002343907,0.00002293088,0.00004236419,0.00004104622],"category_scores_gemma":[0.0001157779,0.0001066094,0.00002302531,0.0001882723,0.0001536804,0.00008668906,0.00005475122,0.0001230276,0.000001839216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001948423,"about_ca_system_score_gemma":0.00004187638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001063793,"about_ca_topic_score_gemma":0.000006012966,"domain_scores_codex":[0.9989955,0.0001010053,0.0001644796,0.0003829899,0.0002139124,0.0001421435],"domain_scores_gemma":[0.999254,0.0001541028,0.0001507783,0.0001719313,0.000182477,0.00008670805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001234801,0.000938155,0.5811105,0.00008773855,0.00006689515,0.002059475,0.0001881318,0.000001664389,0.411456,0.0005277119,0.00004436168,0.002284656],"study_design_scores_gemma":[0.001674506,0.001692822,0.8498522,0.00009189966,0.0001755851,0.0009119778,0.00005154114,0.00008651136,0.1451635,0.00001010413,0.0001944633,0.00009490194],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976453,0.00007584038,0.00005112429,0.0009861598,0.0000157694,0.0004154231,0.00002451687,0.00003330667,0.0007525968],"genre_scores_gemma":[0.9983232,0.00005210393,0.001298511,0.0001729564,0.00001728702,0.00005441555,0.00004209273,0.00001854472,0.0000208667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2687418,"threshold_uncertainty_score":0.4347404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324813185827183,"score_gpt":0.2396920326619073,"score_spread":0.2264439008036355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}