{"id":"W3152824761","doi":"10.1007/s00401-021-02302-6","title":"Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Universitätsklinikum Heidelberg; Friedberg Charitable Foundation; Medical Research Council; Deutschen Konsortium für Translationale Krebsforschung; University College London Hospitals NHS Foundation Trust; Deutsche Krebshilfe; Making Headway Foundation; National Institute for Health and Care Research; Else Kröner-Fresenius-Stiftung; Deutsche Forschungsgemeinschaft","keywords":"CDKN2A; PTEN; Biology; Primitive neuroectodermal tumor; Pathology; Phenotype; Histology; DNA methylation; Cancer research; Immunohistochemistry; Cancer; Genetics; Medicine; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001207203,0.0002461566,0.0003540885,0.0005811894,0.0002328218,0.0002505711,0.0001380989,0.00008524605,0.0007753397],"category_scores_gemma":[0.0004298827,0.00009706161,0.0001430307,0.0004288713,0.0002443469,0.0001163678,0.0002838498,0.0001347848,0.0001836943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002295417,"about_ca_system_score_gemma":0.0002844558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001635529,"about_ca_topic_score_gemma":0.004385527,"domain_scores_codex":[0.9998978,0.000008654692,0.00001713023,0.00001781449,0.00003066752,0.0000278292],"domain_scores_gemma":[0.9998091,0.00001669147,0.00007285392,0.00003136643,0.00002167342,0.00004836447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008238051,0.00006686067,0.8016567,0.000142192,0.0001119729,0.01599867,0.000387987,0.0003310293,0.1369182,0.0003982459,0.0004351856,0.04272905],"study_design_scores_gemma":[0.00001750941,0.0002517226,0.9325722,0.00001313475,0.00006382763,0.05140098,0.0003071077,0.0003601911,0.01335204,0.0004917312,0.001157891,0.00001177476],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987034,0.0001978551,0.0003979068,0.00001298701,0.000002346557,0.0000121791,0.0001731815,0.00001781379,0.0004822383],"genre_scores_gemma":[0.9990898,0.0001163736,0.0002892523,0.000007416702,0.000002745146,0.000004474898,0.0003010339,0.000002652832,0.0001862477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001635529,"threshold_uncertainty_score":0.003252089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324813185827183,"score_gpt":0.2396920326619073,"score_spread":0.2264439008036355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}