{"id":"W3152835287","doi":"10.1016/j.jhep.2021.03.013","title":"A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure","year":2021,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; University of Alberta","funders":"Baylor University Medical Center; University of Alberta; University of California, San Diego; University of Oregon; University of Pittsburgh; University of California, Los Angeles; University of South Carolina; National Institute of Diabetes and Digestive and Kidney Diseases; Baylor University; Yale University; Virginia Commonwealth University; Northwestern University; Ohio State University; University of Washington; Roche Organ Transplant Research Foundation; Emory University; University of Pennsylvania; Massachusetts General Hospital","keywords":"Medicine; microRNA; Logistic regression; Acetaminophen; Internal medicine; Proportional hazards model; Liver failure; Time point; Oncology; Liver injury; Pharmacology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002132568,0.001101865,0.001322243,0.0008116091,0.0003711538,0.00153519,0.0005418329,0.0007789874,0.001906347],"category_scores_gemma":[0.005576524,0.0002521572,0.001315068,0.0006397229,0.0001959363,0.000862678,0.000697039,0.0009777397,0.0005855757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004617548,"about_ca_system_score_gemma":0.001001216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002348779,"about_ca_topic_score_gemma":0.003053137,"domain_scores_codex":[0.999261,0.0002758132,0.00007990709,0.0001748477,0.0001187666,0.00008969735],"domain_scores_gemma":[0.998226,0.0009906073,0.0002852976,0.00007460966,0.0002860654,0.0001373389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.005293087,0.0005456784,0.8232525,0.000245366,0.001689137,0.0004782483,0.00008312076,0.04142523,0.002404887,0.0005786686,0.006005277,0.1179988],"study_design_scores_gemma":[0.000306179,0.001446716,0.1773232,0.0001426016,0.002057143,0.0006931745,0.0001915798,0.8088425,0.002797785,0.0028697,0.003224239,0.0001051994],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.954022,0.003569784,0.03288525,0.002151811,0.0005130831,0.0001065367,0.003579288,0.0006997274,0.002472434],"genre_scores_gemma":[0.9912259,0.0003529684,0.005470076,0.0002188297,0.0001862299,0.00005060455,0.001932409,0.00002589357,0.0005371977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002348779,"threshold_uncertainty_score":0.01127821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07410665376391912,"score_gpt":0.3395325928580135,"score_spread":0.2654259390940943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}