{"id":"W3152848291","doi":"10.1186/s13104-021-05663-z","title":"A novel blood-based assay for treatment monitoring of tuberculosis","year":2021,"lang":"en","type":"article","venue":"BMC Research Notes","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Ministerie van Buitenlandse Zaken; Australian Government; Department for International Development; National Institutes of Health; U.S. Department of Defense; Department for International Development, UK Government; Department of Foreign Affairs and Trade, Australian Government; Bill and Melinda Gates Foundation; Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie; Universidad Peruana Cayetano Heredia; Dr. Ralph and Marian Falk Medical Research Trust","keywords":"GeneXpert MTB/RIF; Medicine; Tuberculosis; Internal medicine; Tb treatment; Gene signature; Prospective cohort study; Sputum; Gene; Gene expression; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002519264,0.0001625857,0.0005815133,0.0003227342,0.0001505079,0.00002315616,0.0001364529,0.0001613975,0.0001105316],"category_scores_gemma":[0.02070891,0.000126138,0.0003384646,0.0005663605,0.000209385,0.00004846638,0.00008015162,0.0002151951,0.00002263463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001918355,"about_ca_system_score_gemma":0.001173408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009255346,"about_ca_topic_score_gemma":0.0001608024,"domain_scores_codex":[0.9970631,0.0004959469,0.0003864317,0.0004806971,0.0006945794,0.0008792207],"domain_scores_gemma":[0.9879504,0.0098269,0.00004516578,0.0006174339,0.001177616,0.0003824478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006186417,0.00155472,0.4645157,0.0005542977,0.0003347939,0.00003760148,0.00006178996,0.00008956026,0.5250509,0.0002881881,0.0004140393,0.006479732],"study_design_scores_gemma":[0.004649427,0.002052642,0.1435089,0.0002563531,0.0001210814,0.00003475846,0.0001858393,0.00272102,0.8433065,0.0001621668,0.002874084,0.000127143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835753,0.002233662,0.004898203,0.007218876,0.0001040988,0.001109286,0.0001078202,0.00004556859,0.0007071657],"genre_scores_gemma":[0.9445423,0.0004247237,0.05319465,0.00006356888,0.0004918847,0.000519549,0.0000833014,0.00003845463,0.0006415492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3210068,"threshold_uncertainty_score":0.9875401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2913481744011678,"score_gpt":0.4755042175429726,"score_spread":0.1841560431418048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}