{"id":"W3152925158","doi":"10.1101/2021.04.15.439909","title":"XBP1s-Mediated ER Proteostasis Network Enhancement Can Selectively Improve the Folding and Secretion of an Osteogenesis Imperfecta-Causing Collagen-I Variant","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Institute of Environmental Health Sciences; G. Harold and Leila Y. Mathers Foundation; Canadian Institutes of Health Research; National Institutes of Health; National Health and Medical Research Council; State Government of Victoria; Camille and Henry Dreyfus Foundation","keywords":"Proteostasis; Unfolded protein response; Secretion; Endoplasmic reticulum; Osteogenesis imperfecta; Cell biology; Chemistry; Type I collagen; Protein folding; XBP1; Procollagen peptidase; Mutant; Secretory protein; Molecular biology; Biology; Biochemistry; Gene; Endocrinology; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001216065,0.0003230802,0.0001939404,0.00008938837,0.00009540709,0.0002073065,0.00009848792,0.0001464786,0.001148186],"category_scores_gemma":[0.00007146091,0.00008250149,0.000190358,0.00008841811,0.0001414321,0.00007443553,0.0001501869,0.0003470749,0.0002679371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000131888,"about_ca_system_score_gemma":0.00009654956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003123662,"about_ca_topic_score_gemma":0.0003403565,"domain_scores_codex":[0.9999105,0.00001938838,0.00001113396,0.00001760871,0.00001778589,0.0000236533],"domain_scores_gemma":[0.9999287,0.00001162096,0.00002347731,0.00000863747,0.000006555931,0.00002094873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001046325,0.00002197561,0.00007099375,0.00001953839,0.000003704767,0.00002992647,0.00000346386,0.00003194588,0.9992592,0.00001756245,0.00002350441,0.0004136411],"study_design_scores_gemma":[0.00001600991,0.000381808,0.001695809,0.000003215507,0.000009522009,0.0001171616,0.00001132401,0.0003215577,0.9965929,0.000009989712,0.0008388052,0.000001753238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973142,0.0007524665,0.0008301726,0.00007361444,0.00002983124,0.0000217751,0.0001935899,0.00004792535,0.0007364196],"genre_scores_gemma":[0.9967713,0.0004811332,0.001064495,0.00006100251,0.00001017396,0.00001646883,0.0003100809,0.00001383756,0.00127141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001148186,"threshold_uncertainty_score":0.003841102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006667110398973668,"score_gpt":0.2088265541777057,"score_spread":0.202159443778732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}