{"id":"W3152973233","doi":"10.1039/d1cc00495f","title":"The Hantzsch reaction for nitrogen-13 PET: preparation of [<sup>13</sup>N]nifedipine and derivatives","year":2021,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Centre For Medical Engineering, King’s College London; King's College London; Engineering and Physical Sciences Research Council; National Institute for Health and Care Research; King's College Hospital NHS Foundation Trust; Cancer Research UK; Wellcome Trust; Wellcome","keywords":"Radiosynthesis; Chemistry; Nifedipine; Radiochemistry; Nitrogen; Pet imaging; Nuclear chemistry; Organic chemistry; Positron emission tomography; Nuclear medicine; Calcium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410505,0.00007412236,0.0001609526,0.00003121655,0.0002332475,0.00002002299,0.0001139854,0.00004289607,0.00001560631],"category_scores_gemma":[0.0006462647,0.00005915757,0.00009939336,0.0002065458,0.0002375964,0.0000658092,0.00009924103,0.0001354766,0.000003090824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002774857,"about_ca_system_score_gemma":0.00006922433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001072978,"about_ca_topic_score_gemma":0.00002273151,"domain_scores_codex":[0.9993452,0.00005559229,0.0002710939,0.0001297149,0.0001042346,0.00009409428],"domain_scores_gemma":[0.9983236,0.0004249589,0.00009921046,0.0007279594,0.0003619455,0.00006232543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000791179,0.0002428501,0.0006327292,0.00005567138,0.0001294588,5.329085e-7,0.000416429,0.000002178521,0.992846,0.002817964,0.001416658,0.001360399],"study_design_scores_gemma":[0.001464537,0.00008311428,0.001017675,0.0002881143,0.0002968245,0.00009446522,0.002323534,0.02004097,0.9484572,0.004091315,0.02168485,0.0001574489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819093,0.001147371,0.0009357313,0.01290842,0.000004682801,0.0002399418,0.00003351408,0.00003668006,0.002784395],"genre_scores_gemma":[0.994106,0.0006612922,0.003948353,0.0001913575,0.00004322459,0.00008974862,0.0005731164,0.000008855532,0.0003780445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04438885,"threshold_uncertainty_score":0.2412376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03651348244811336,"score_gpt":0.341950001845735,"score_spread":0.3054365193976216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}