{"id":"W3152976902","doi":"10.1016/j.joca.2021.02.174","title":"Regulation of key extracellular matrix components in human osteoarthritis fibroblast-like synoviocytes by microrna-27b-3p via peroxisome proliferator-activated receptor gamma/a disintegrin and metalloproteinase with thrombospondin motifs-8 signaling axis","year":2021,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Arthritis Society","funders":"","keywords":"Extracellular matrix; Osteoarthritis; Thrombospondin; microRNA; Synovitis; Fibroblast; Pathology; Cartilage; Synovial joint; Chemistry; In situ hybridization; Cell biology; Cancer research; Matrix metalloproteinase; Medicine; Biology; Arthritis; Immunology; Messenger RNA; Internal medicine; Anatomy; Metalloproteinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000221981,0.000360191,0.0003214295,0.0004230689,0.0003030211,0.0004968503,0.0001374962,0.0002658455,0.001580245],"category_scores_gemma":[0.0002521273,0.0002423444,0.0003130143,0.0001551221,0.0002329063,0.0001559951,0.00037056,0.000478899,0.0005030619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003412593,"about_ca_system_score_gemma":0.0004336815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008490923,"about_ca_topic_score_gemma":0.001442046,"domain_scores_codex":[0.999657,0.00006064497,0.00003053448,0.0000586164,0.0001033959,0.00008981476],"domain_scores_gemma":[0.9998897,0.00001271872,0.00003710336,0.000006062737,0.0000258311,0.00002858051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000376248,0.00003998375,0.001273208,0.0000626753,0.00001613848,0.000256237,0.00005326021,0.00004055345,0.9947814,0.000235437,0.0003140263,0.002550703],"study_design_scores_gemma":[0.000315088,0.0007190857,0.1182275,0.0000522377,0.0001695865,0.001642989,0.0005405784,0.003676137,0.8589985,0.0006070521,0.01501167,0.00003950233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815323,0.006952138,0.004445174,0.0005071873,0.0002542897,0.00009994222,0.001091903,0.0001547797,0.004962292],"genre_scores_gemma":[0.9927801,0.001017558,0.001941588,0.0003005218,0.00002438894,0.00009602094,0.0007054748,0.00003243296,0.003101812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001580245,"threshold_uncertainty_score":0.005286396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009256233214941553,"score_gpt":0.2199251303720654,"score_spread":0.2106688971571238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}