{"id":"W3152988358","doi":"10.1016/s2213-2600(21)00097-7","title":"Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial","year":2021,"lang":"en","type":"letter","venue":"The Lancet Respiratory Medicine","topic":"Sinusitis and nasal conditions","field":"Medicine","cited_by":580,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Allergy Therapeutics; Novartis; GlaxoSmithKline","keywords":"Medicine; Nasal polyps; Mepolizumab; Chronic rhinosinusitis; Placebo; Double blind; Internal medicine; Randomized controlled trial; Gastroenterology; Asthma; Alternative medicine; Pathology; Eosinophil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002056033,0.001125075,0.004897556,0.0005403369,0.0005914039,0.0001040092,0.0007010997,0.001109494,0.001886976],"category_scores_gemma":[0.0006891807,0.0006304838,0.0008362368,0.000645212,0.0009772826,0.0001243475,0.00009489914,0.003439991,0.0000443758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006061288,"about_ca_system_score_gemma":0.002699774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001351002,"about_ca_topic_score_gemma":0.0001525742,"domain_scores_codex":[0.9936041,0.0006791271,0.001557221,0.001184678,0.00154425,0.001430646],"domain_scores_gemma":[0.9935914,0.002294303,0.00103138,0.002056906,0.000679274,0.0003467461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5011064,0.0001142539,0.000002313683,0.0003470354,0.001181756,0.001972843,0.00009842038,0.000001288171,0.000354545,0.00008886122,0.4944598,0.0002724807],"study_design_scores_gemma":[0.583509,0.007141502,0.000005503512,0.001248853,0.003238362,0.0006325447,0.00004625152,0.00002019975,0.0002054369,0.00001473827,0.4035171,0.0004205355],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.08440802,0.03126476,0.0008256788,0.8282685,0.00434105,0.03650986,0.0009411325,0.0006081612,0.01283286],"genre_scores_gemma":[0.02509262,0.0002970966,0.000110449,0.745966,0.2052857,0.009682157,0.004022754,0.000460536,0.009082733],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2009447,"threshold_uncertainty_score":0.9996147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1069885515465855,"score_gpt":0.3699421946416087,"score_spread":0.2629536430950232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}