{"id":"W3153049780","doi":"10.1101/2021.04.14.437578","title":"Life without mismatch repair","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; London Health Sciences Centre; SickKids Foundation; Izaak Walton Killam Health Centre; Hospital for Sick Children","funders":"KWF Kankerbestrijding; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancer Research UK; Wellcome Trust","keywords":"DNA mismatch repair; Biology; MSH2; Somatic hypermutation; Genetics; MSH6; PMS2; DNA replication; Neoplastic transformation; Indel; DNA repair; Cancer research; Carcinogenesis; Genotype; DNA; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000593092,0.0007449037,0.0005525795,0.0005585451,0.0008571207,0.002324262,0.0004645982,0.001326028,0.05622111],"category_scores_gemma":[0.001363848,0.0002855103,0.0004248447,0.000583648,0.0006740183,0.001857296,0.001328432,0.001945756,0.06896282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007064995,"about_ca_system_score_gemma":0.0005928026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002964578,"about_ca_topic_score_gemma":0.0003092009,"domain_scores_codex":[0.9994693,0.0000621295,0.00002619608,0.0001681151,0.00021593,0.0000582695],"domain_scores_gemma":[0.9991546,0.00009203008,0.00008996356,0.0003901421,0.0001393238,0.0001339913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005756952,0.0001901235,0.003248325,0.001420619,0.0001702629,0.001007366,0.000338322,0.001168701,0.1742669,0.315325,0.2155871,0.2867016],"study_design_scores_gemma":[0.00002626965,0.0001045973,0.001411893,0.00009339568,0.00002057313,0.001036149,0.00004907939,0.0004981298,0.03613213,0.03882051,0.9217829,0.00002426804],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.07126057,0.041238,0.09620366,0.0374128,0.02922369,0.0002386112,0.03452332,0.009822942,0.6800765],"genre_scores_gemma":[0.2852871,0.01405148,0.0451225,0.006160571,0.003151502,0.0002496468,0.02766988,0.0016002,0.6167071],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.05622111,"threshold_uncertainty_score":0.1880783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01017680155024297,"score_gpt":0.2197292038484982,"score_spread":0.2095524022982553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}