{"id":"W3153049780","doi":"10.1101/2021.04.14.437578","title":"Life without mismatch repair","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; London Health Sciences Centre; SickKids Foundation; Izaak Walton Killam Health Centre; Hospital for Sick Children","funders":"KWF Kankerbestrijding; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancer Research UK; Wellcome Trust","keywords":"DNA mismatch repair; Biology; MSH2; Somatic hypermutation; Genetics; MSH6; PMS2; DNA replication; Neoplastic transformation; Indel; DNA repair; Cancer research; Carcinogenesis; Genotype; DNA; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003274895,0.000550683,0.0005317215,0.00008729213,0.0001225396,0.0002311276,0.0005060759,0.0008039282,0.00004623387],"category_scores_gemma":[0.0009155595,0.0006541971,0.0003706044,0.0001715438,0.0001072782,0.00000512214,0.001087337,0.0004856973,0.00003058421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001002485,"about_ca_system_score_gemma":0.002264351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009421162,"about_ca_topic_score_gemma":0.00001661802,"domain_scores_codex":[0.9973198,0.00009119243,0.0004984845,0.001294172,0.0002651021,0.0005312436],"domain_scores_gemma":[0.9965845,0.00002261629,0.0003029705,0.002010538,0.0005298236,0.0005495894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005118367,0.0001600978,0.01659858,0.0002985677,0.0004016257,0.00005934817,0.000006133324,0.0002344788,0.9719732,0.00009729515,0.01011815,0.000001363003],"study_design_scores_gemma":[0.0009765397,0.0001497517,0.03216964,0.0003260668,0.000275277,6.588594e-8,0.00001301642,0.0003221897,0.8353504,0.000001131717,0.1286978,0.001718096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876821,0.007828169,0.00153145,0.0002763938,0.001767901,0.0004446466,0.0002595962,0.0001683691,0.00004139904],"genre_scores_gemma":[0.985833,0.002492933,0.008002494,0.001653711,0.001647378,0.0001612206,0.000004994679,0.0001784961,0.00002581353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1366228,"threshold_uncertainty_score":0.9995909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01017680155024297,"score_gpt":0.2197292038484982,"score_spread":0.2095524022982553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}