{"id":"W3153071119","doi":"10.1038/s41523-021-00251-7","title":"Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer","year":2021,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute for Health and Care Research; Astex Pharmaceuticals; Memorial Sloan-Kettering Cancer Center; AstraZeneca; National Cancer Institute; National Institutes of Health; Cancer Research UK; Breast Cancer Research Foundation","keywords":"Fulvestrant; PTEN; Medicine; Metastatic breast cancer; Breast cancer; Oncology; Internal medicine; Anastrozole; Cancer; Aromatase inhibitor; Cancer research; Estrogen receptor; PI3K/AKT/mTOR pathway; Biology; Aromatase; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000325469,0.0003829784,0.0006034681,0.0002127317,0.0001210192,0.0002776156,0.0002625207,0.0001806363,0.0007010548],"category_scores_gemma":[0.0002248597,0.0001466328,0.000303558,0.0002393425,0.0001638483,0.000217447,0.000149503,0.0006753085,0.0001185338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002940003,"about_ca_system_score_gemma":0.0003342359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004696677,"about_ca_topic_score_gemma":0.001607688,"domain_scores_codex":[0.9999156,0.00002858779,0.000006088376,0.0000124181,0.00001637312,0.00002101553],"domain_scores_gemma":[0.9999235,0.00001532967,0.00001640579,0.000009257391,0.000005756708,0.0000297411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.09687041,0.01834936,0.01223193,0.0008346323,0.001012581,0.0009033727,0.0002645549,0.009823129,0.4219972,0.0004411922,0.003723692,0.4335479],"study_design_scores_gemma":[0.07169142,0.5608852,0.1123623,0.0001421543,0.001627463,0.0042021,0.0002450089,0.01817442,0.2128204,0.0005263651,0.01723198,0.00009105365],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970731,0.001809975,0.0001744271,0.00007984627,0.00002266124,0.00009701674,0.0000957914,0.00003060629,0.0006166486],"genre_scores_gemma":[0.9974294,0.001416831,0.0003029251,0.00006779048,0.00002642027,0.00007741495,0.0002029982,0.000004710612,0.0004714289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007010548,"threshold_uncertainty_score":0.002345204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007119816247072573,"score_gpt":0.2537711970203723,"score_spread":0.2466513807732997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}