{"id":"W3153072995","doi":"10.2220/biomedres.42.85","title":"High-fructose diet-induced hepatic expression of the &lt;i&gt;Scd1&lt;/i&gt; gene is associated with increased acetylation of histones H3 and H4 and the binding of ChREBP at the &lt;i&gt;Scd1 &lt;/i&gt;promoter in rats","year":2021,"lang":"en","type":"article","venue":"Biomedical Research","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Japan Society for the Promotion of Science","keywords":"Carbohydrate-responsive element-binding protein; Acetylation; Chemistry; Fructose; Histone; Gene expression; Promoter; Biochemistry; Internal medicine; Endocrinology; Gene; Biology; Transcription factor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179796,0.0003960795,0.0003276127,0.0005293604,0.0002002738,0.0001832049,0.0001425884,0.0002196288,0.001765052],"category_scores_gemma":[0.00009645395,0.0003200294,0.0004504214,0.0002620798,0.0004710637,0.0001941758,0.0001675623,0.0007743506,0.0001834556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004155567,"about_ca_system_score_gemma":0.0002436314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001864679,"about_ca_topic_score_gemma":0.002663118,"domain_scores_codex":[0.9998759,0.0000164795,0.000009241295,0.00003460821,0.00002027662,0.00004339616],"domain_scores_gemma":[0.9997944,0.0000194602,0.00006617482,0.00001759717,0.00001746427,0.00008483888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001271822,0.0001459809,0.0009549276,0.00002825857,0.0000176607,0.00006538541,0.00002735268,0.00005009034,0.9961609,0.00008381205,0.00004221245,0.001151625],"study_design_scores_gemma":[0.000124057,0.001639293,0.03984073,0.0000106699,0.0000887828,0.0002694547,0.0001245397,0.000951626,0.9558228,0.0001471788,0.0009571933,0.00002363948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980729,0.0002432139,0.001104831,0.00006950601,0.00002570617,0.000008531348,0.0001861905,0.00003608628,0.0002530716],"genre_scores_gemma":[0.9932045,0.0004217414,0.00201233,0.00009371776,0.00001906858,0.00005732437,0.0005295748,0.00003117296,0.00363063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001864679,"threshold_uncertainty_score":0.005904675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0294829408518685,"score_gpt":0.3036722405395981,"score_spread":0.2741892996877296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}