{"id":"W3153177353","doi":"10.3390/cancers13092016","title":"Tumor Long Interspersed Nucleotide Element-1 (LINE-1) Hypomethylation in Relation to Age of Colorectal Cancer Diagnosis and Prognosis","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Gary Bennett Family Fund; National Institutes of Health; Huazhong University of Science and Technology; Harvard T.H. Chan School of Public Health; Mitsukoshi Health and Welfare Foundation; American Association for Cancer Research; American Society of Clinical Oncology; Massachusetts General Hospital; Conquer Cancer Foundation; National Cancer Institute; Entertainment Industry Foundation; Brigham and Women's Hospital; Japan Society for the Promotion of Science; American Cancer Society; Research Promotion Foundation; Stand Up To Cancer; Uehara Memorial Foundation","keywords":"Colorectal cancer; Medicine; Confidence interval; Hazard ratio; Internal medicine; Gastroenterology; Methylation; Cancer; DNA methylation; Oncology; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009070963,0.0001168533,0.0002962153,0.0001484157,0.00003120965,0.00001100909,0.00003254596,0.00003477641,0.0001277325],"category_scores_gemma":[0.0001423599,0.0001175651,0.00005719183,0.0004678759,0.00005531282,0.00007242847,0.00004747966,0.0001037882,0.000001636668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000934705,"about_ca_system_score_gemma":0.000263287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001381258,"about_ca_topic_score_gemma":0.005464354,"domain_scores_codex":[0.9990954,0.00002400745,0.0002575558,0.0002792302,0.0001638519,0.000179968],"domain_scores_gemma":[0.9995588,0.00005967594,0.00007193492,0.00009497644,0.0001256868,0.00008894542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002294459,0.00003370177,0.9730728,0.0001431531,0.0001066845,0.0001001911,0.003508467,0.0002075437,0.01280663,0.00001934569,0.0007653983,0.009006682],"study_design_scores_gemma":[0.001400982,0.0002124438,0.9606041,0.0004195879,0.0001045706,0.000004275059,0.001255977,0.0001987759,0.03497599,0.000009963765,0.0006969628,0.0001163978],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935001,0.003863861,0.00004075202,0.0014146,0.0001861564,0.0004632648,0.00002354357,0.0000176517,0.0004901128],"genre_scores_gemma":[0.9976531,0.0007442822,0.0005344206,0.000439251,0.00007280313,0.0004487653,0.00002530406,0.00001673353,0.00006533288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02216936,"threshold_uncertainty_score":0.4794165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02757196310871911,"score_gpt":0.2970717674627565,"score_spread":0.2694998043540374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}