{"id":"W3153228158","doi":"10.1016/s1470-2045(21)00065-6","title":"Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":389,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Merck","keywords":"Medicine; Pembrolizumab; Hazard ratio; Internal medicine; Placebo; Clinical endpoint; Population; Oncology; Clinical trial; Melanoma; Surgery; Cancer; Confidence interval; Pathology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003241471,0.0004830773,0.002990994,0.0002555299,0.0002067954,0.00008649786,0.0005976369,0.0003260984,0.001115229],"category_scores_gemma":[0.00267321,0.000342249,0.0004478196,0.0005885836,0.0002178329,0.00007855154,0.0004076768,0.0009996493,0.00007658911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007148786,"about_ca_system_score_gemma":0.000795548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001420428,"about_ca_topic_score_gemma":0.01609457,"domain_scores_codex":[0.9939401,0.001947105,0.001501403,0.0009299711,0.000754947,0.0009264355],"domain_scores_gemma":[0.993312,0.003665282,0.0006034241,0.001909187,0.0002314431,0.0002786733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9770991,0.00143585,0.00000580874,0.00003691756,0.001466845,0.00586451,0.0008143478,0.00007757153,0.002582865,0.001022716,0.005896028,0.003697431],"study_design_scores_gemma":[0.8765273,0.003651866,0.00004002781,0.00004613048,0.001039843,0.0001225961,0.001340158,0.0009614464,0.001029781,0.0001519931,0.1147795,0.0003093476],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9241124,0.000793747,0.0003345082,0.01227583,0.005089862,0.007005792,0.0005906962,0.0002378783,0.0495593],"genre_scores_gemma":[0.9870614,0.0006278308,0.0003425937,0.0007439847,0.002721115,0.0009091937,0.0007618055,0.00007114777,0.006760954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1088835,"threshold_uncertainty_score":0.999903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1008113264955529,"score_gpt":0.3732081519797956,"score_spread":0.2723968254842428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}