{"id":"W3153234978","doi":"10.1101/2021.04.13.439587","title":"The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Bundesministerium für Bildung, Wissenschaft und Forschung; Austrian Science Fund; Österreichischen Akademie der Wissenschaften","keywords":"Ubiquitin ligase; Ubiquitin; Immune system; Inflammation; Cytokine; Zinc finger; Tumor necrosis factor alpha; Receptor; Ubiquitin-Protein Ligases","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001184133,0.0003093238,0.0001802963,0.000207935,0.0001399182,0.0003154471,0.0001412515,0.0002104801,0.001747225],"category_scores_gemma":[0.00009274647,0.0001173118,0.0001299939,0.0001362112,0.0001952516,0.0001942433,0.0002234524,0.0001974633,0.00133648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003053425,"about_ca_system_score_gemma":0.00009510924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001795715,"about_ca_topic_score_gemma":0.0002446208,"domain_scores_codex":[0.999935,0.000008789584,0.000002848894,0.00001556814,0.00002197831,0.00001583168],"domain_scores_gemma":[0.9999604,0.000004391969,0.00001342181,0.000005717945,0.000004702463,0.00001134372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001715868,0.00002608616,0.0009970395,0.00004267667,0.000009395901,0.0001511827,0.00001396286,0.0004006254,0.9933032,0.0007680664,0.0005459828,0.003570124],"study_design_scores_gemma":[0.0000439394,0.00007150484,0.007674142,0.000008129748,0.00001397069,0.0004347745,0.0000229885,0.01174467,0.9722268,0.000862964,0.006888494,0.000007608606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975397,0.002091201,0.01683764,0.0003578456,0.00005968636,0.00002201404,0.000566652,0.0005669404,0.004101202],"genre_scores_gemma":[0.9855173,0.000767317,0.005010574,0.00004283609,0.00002331055,0.000014733,0.0007291124,0.00007141994,0.007823369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001747225,"threshold_uncertainty_score":0.00584501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007001110364398,"score_gpt":0.2250541466388208,"score_spread":0.2149841355351768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}