{"id":"W3153255378","doi":"10.3390/cancers13081905","title":"Contemporary Neoadjuvant Therapies for High-Risk Melanoma: A Systematic Review","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Ottawa Hospital","funders":"Genentech; Sanofi; AstraZeneca; Bristol-Myers Squibb","keywords":"Medicine; Ipilimumab; Nivolumab; Trametinib; Neoadjuvant therapy; Dabrafenib; Oncology; Internal medicine; Melanoma; Adverse effect; Randomized controlled trial; Adjuvant therapy; Clinical trial; Pembrolizumab; Vemurafenib; Targeted therapy; Immunotherapy; Cancer; Metastatic melanoma; Breast cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004437133,0.0004764777,0.00483797,0.0001475572,0.00008893074,0.00003449064,0.0001697263,0.0001809641,0.0001892733],"category_scores_gemma":[0.0003023107,0.0003319235,0.001093674,0.0002936132,0.00004324411,0.00002690609,0.00004787279,0.0002936127,0.00006580946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00150153,"about_ca_system_score_gemma":0.001615137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001307004,"about_ca_topic_score_gemma":0.00001486797,"domain_scores_codex":[0.9976718,0.0002490389,0.001030033,0.0005232822,0.0002663706,0.0002594693],"domain_scores_gemma":[0.9978144,0.0002433393,0.0008493813,0.000805549,0.0001389058,0.000148426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008163588,0.000009392109,8.975771e-8,0.831652,0.001639667,0.0001449853,0.00002378943,1.090587e-7,4.5023e-8,0.00008007871,0.04494247,0.1214992],"study_design_scores_gemma":[0.0002618082,0.0001337837,2.647639e-8,0.4431859,0.007548542,0.0002214158,0.00006017755,0.000001705324,2.325608e-7,0.000003445361,0.5484056,0.0001772799],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[2.957883e-7,0.9870901,0.0001799389,0.0001265954,0.001061732,0.009998605,0.0001403065,0.0001165077,0.001285905],"genre_scores_gemma":[0.00001009586,0.9861813,0.0001502057,0.001025505,0.0002930284,0.003815835,0.0003174876,0.00009871988,0.008107823],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5034632,"threshold_uncertainty_score":0.9999133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04759316607840568,"score_gpt":0.3219973152292175,"score_spread":0.2744041491508118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}