{"id":"W3153255378","doi":"10.3390/cancers13081905","title":"Contemporary Neoadjuvant Therapies for High-Risk Melanoma: A Systematic Review","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Ottawa Hospital","funders":"Genentech; Sanofi; AstraZeneca; Bristol-Myers Squibb","keywords":"Medicine; Ipilimumab; Nivolumab; Trametinib; Neoadjuvant therapy; Dabrafenib; Oncology; Internal medicine; Melanoma; Adverse effect; Randomized controlled trial; Adjuvant therapy; Clinical trial; Pembrolizumab; Vemurafenib; Targeted therapy; Immunotherapy; Cancer; Metastatic melanoma; Breast cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004947347,0.001192855,0.008317147,0.006605179,0.000423315,0.001869877,0.001628302,0.001336059,0.004156339],"category_scores_gemma":[0.0140254,0.0007251176,0.005825566,0.008152411,0.0007099288,0.001757682,0.000961818,0.0008286952,0.000297352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00229496,"about_ca_system_score_gemma":0.006248299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004655494,"about_ca_topic_score_gemma":0.01558634,"domain_scores_codex":[0.9965431,0.001128965,0.001388307,0.0002674671,0.0005610691,0.0001110918],"domain_scores_gemma":[0.9865298,0.009010958,0.002924679,0.0001606881,0.001167278,0.0002065101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0003099418,0.00001579173,0.0004611848,0.9626243,0.007706385,0.00007794519,0.000104336,0.00006774696,0.0001596435,0.0001157773,0.001170864,0.02718615],"study_design_scores_gemma":[0.0006707239,0.0004411237,0.004774896,0.8721446,0.1012599,0.0004997452,0.0002759768,0.0001255046,0.0002309205,0.0003047985,0.01922583,0.00004597588],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008703811,0.9983093,0.0000843402,0.0001393191,0.00005374335,0.0001767756,0.0001972737,0.000005130601,0.0001638065],"genre_scores_gemma":[0.01083479,0.9875898,0.0003791306,0.0004448502,0.00006663059,0.0003745796,0.0002019646,0.000003825395,0.0001044048],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008317147,"threshold_uncertainty_score":0.02616441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04759316607840568,"score_gpt":0.3219973152292175,"score_spread":0.2744041491508118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}