{"id":"W3153283316","doi":"10.1371/journal.pgen.1009525","title":"Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto","funders":"National Institute of Dental and Craniofacial Research; National Institute of Environmental Health Sciences; National Cancer Institute; World Cancer Research Fund; University of Bristol; Diabetes UK; National Institute for Health and Care Research; National Institutes of Health; Cancer Research UK; Academy of Medical Sciences; Wellcome Trust; Medical Research Council; Wellcome; Division of Cancer Prevention, National Cancer Institute; World Health Organization","keywords":"Mendelian randomization; Ezetimibe; Biology; Genome-wide association study; Internal medicine; Head and neck squamous-cell carcinoma; Oncology; Statin; Cholesterol; PCSK9; Bioinformatics; Cancer; Genetics; Head and neck cancer; Medicine; Endocrinology; Single-nucleotide polymorphism; LDL receptor; Lipoprotein; Genetic variants; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002662914,0.0001908483,0.0002838497,0.00003905404,0.0001055106,0.00003475411,0.0001161354,0.00007429208,0.00001067422],"category_scores_gemma":[0.0001301484,0.0001471644,0.0000577024,0.0001336977,0.00003429158,0.000002169851,0.0001307583,0.00008369443,0.000001236337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000178534,"about_ca_system_score_gemma":0.0001030636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008637193,"about_ca_topic_score_gemma":0.0004151225,"domain_scores_codex":[0.9985994,0.0003120355,0.00025828,0.0003846732,0.0002306308,0.0002149471],"domain_scores_gemma":[0.99924,0.00003046532,0.00008412625,0.0004232212,0.0001326928,0.00008942488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008323416,0.000172831,0.03873173,0.00005454385,0.0003228215,5.55599e-7,0.000597035,0.0280039,0.9246231,5.624988e-7,0.0001270369,0.006533527],"study_design_scores_gemma":[0.01197314,0.001781124,0.0723052,0.0001193509,0.0009620346,0.0000128754,0.0001179444,0.007194674,0.9028203,0.000007613294,0.002344175,0.0003615652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939394,0.003094087,0.0007413925,0.00003239758,0.001322743,0.0007977982,0.00003825308,0.000005216402,0.00002869958],"genre_scores_gemma":[0.9962603,0.001319708,0.0003012131,0.0001296985,0.001833262,0.00007373402,0.000007844732,0.00003515294,0.00003910814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03357347,"threshold_uncertainty_score":0.6001189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02387906496212018,"score_gpt":0.3128825159349056,"score_spread":0.2890034509727854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}