{"id":"W3153283316","doi":"10.1371/journal.pgen.1009525","title":"Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto","funders":"National Institute of Dental and Craniofacial Research; National Institute of Environmental Health Sciences; National Cancer Institute; World Cancer Research Fund; University of Bristol; Diabetes UK; National Institute for Health and Care Research; National Institutes of Health; Cancer Research UK; Academy of Medical Sciences; Wellcome Trust; Medical Research Council; Wellcome; Division of Cancer Prevention, National Cancer Institute; World Health Organization","keywords":"Mendelian randomization; Ezetimibe; Biology; Genome-wide association study; Internal medicine; Head and neck squamous-cell carcinoma; Oncology; Statin; Cholesterol; PCSK9; Bioinformatics; Cancer; Genetics; Head and neck cancer; Medicine; Endocrinology; Single-nucleotide polymorphism; LDL receptor; Lipoprotein; Genetic variants; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03822383,0.001650458,0.002138357,0.001185016,0.0007326671,0.001240675,0.001530537,0.001707259,0.002402223],"category_scores_gemma":[0.07704549,0.0008295307,0.00444465,0.001539856,0.001222269,0.0006957438,0.0008620709,0.001200352,0.0002653403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008068494,"about_ca_system_score_gemma":0.0008813727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004089769,"about_ca_topic_score_gemma":0.002151727,"domain_scores_codex":[0.9341053,0.05379549,0.002440215,0.006962598,0.001956119,0.0007401585],"domain_scores_gemma":[0.953532,0.03217864,0.004310897,0.008442203,0.00101066,0.0005255751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1607657,0.00169502,0.5788049,0.002040664,0.138024,0.003388837,0.001315998,0.01592845,0.01190302,0.01828364,0.003924733,0.06392512],"study_design_scores_gemma":[0.08091088,0.04112475,0.3773017,0.0005998347,0.1797346,0.007468919,0.0005078862,0.232465,0.01121025,0.05067279,0.01725294,0.0007505428],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9109224,0.003591551,0.07932597,0.0006465109,0.0004055957,0.001815858,0.001569273,0.0003248492,0.001397985],"genre_scores_gemma":[0.9755052,0.0002716316,0.02192156,0.0003289445,0.00007796221,0.0009194209,0.0005108775,0.0000456216,0.0004188227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03822383,"threshold_uncertainty_score":0.2021494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02387906496212018,"score_gpt":0.3128825159349056,"score_spread":0.2890034509727854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}