{"id":"W3153373804","doi":"10.1158/2159-8290.cd-20-0963","title":"Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Medical Research Council; Universitätsklinikum Heidelberg; University College London Hospitals NHS Foundation Trust; Deutsche Kinderkrebsstiftung; Deutscher Akademischer Austauschdienst; Japan Society for the Promotion of Science; Friedberg Charitable Foundation; Else Kröner-Fresenius-Stiftung; University of Cambridge; Cancer Research UK; Deutsche Krebshilfe; Japan Agency for Medical Research and Development; National Institute for Health and Care Research; Russian Science Foundation; Russell Sage Foundation; Making Headway Foundation; CERN; Deutsches Krebsforschungszentrum","keywords":"Genomics; Computational biology; Biology; Functional genomics; Genome; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001274209,0.0002640254,0.0005193148,0.0001066825,0.0001174072,0.0001987659,0.0001063742,0.0001480442,0.0008891027],"category_scores_gemma":[0.0001101236,0.0002293379,0.0002404055,0.0003261406,0.0001086007,0.0003605344,0.0001492833,0.0002072043,0.0000567218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001126495,"about_ca_system_score_gemma":0.0008445999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006032891,"about_ca_topic_score_gemma":0.001421207,"domain_scores_codex":[0.9981065,0.00006328941,0.0004170765,0.0005835504,0.0003839826,0.000445559],"domain_scores_gemma":[0.998973,0.0001320008,0.0001131153,0.0004237444,0.0002022256,0.0001559432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006770297,0.0008718892,0.7337178,0.0001095473,0.0004074525,0.00442968,0.00096128,0.0002008801,0.2529853,0.001622691,0.002218856,0.001797658],"study_design_scores_gemma":[0.004327797,0.000152667,0.6915601,0.0003203577,0.0002135692,0.0001533285,0.0006260938,0.00001278199,0.2956499,0.0002981485,0.006381647,0.0003035762],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985091,0.008567755,0.00001282087,0.0008404227,0.001721359,0.0003934032,0.0004019502,0.00002661013,0.002944635],"genre_scores_gemma":[0.986759,0.003564517,0.0000973911,0.0004886464,0.001022864,0.0001804968,0.0002087715,0.00003730568,0.007641005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04266461,"threshold_uncertainty_score":0.9735051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02743783806752251,"score_gpt":0.3059958807102211,"score_spread":0.2785580426426986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}