{"id":"W3153454112","doi":"10.1016/j.devcel.2021.04.001","title":"Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease","year":2021,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"National Institute of Environmental Health Sciences; National Institutes of Health; National Cancer Institute; National Human Genome Research Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Drug Abuse","keywords":"Epigenome; Cytotrophoblast; Biology; DNA methylation; Placenta; Transcriptome; Placentation; Histone; Epigenetics; Syncytiotrophoblast; Genetics; Offspring; Pregnancy; Gene; Fetus; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004804263,0.0001477034,0.0001702646,0.0000725711,0.0001753012,0.00002646217,0.00003119936,0.00004243592,0.0001641372],"category_scores_gemma":[0.00001282219,0.0001551377,0.00003318646,0.0001295004,0.0000584973,0.0001107944,0.0001014626,0.000138742,0.00002412376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003373718,"about_ca_system_score_gemma":0.0001500543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002675753,"about_ca_topic_score_gemma":0.0004440155,"domain_scores_codex":[0.9991056,0.00003361519,0.0002230225,0.0002749063,0.0001533874,0.0002094131],"domain_scores_gemma":[0.9996963,0.00002430939,0.00003669121,0.00008486704,0.00002152952,0.0001362922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002504963,0.0005558702,0.97322,0.0002877565,0.00005173948,0.0008548063,0.004165173,0.00002124679,0.01897478,0.0004707208,0.0003211556,0.000826283],"study_design_scores_gemma":[0.002211445,0.00004130346,0.992085,0.000180482,0.00002833287,0.00004218101,0.001509804,0.0003374591,0.002809527,0.0001003968,0.0004493535,0.0002046692],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898748,0.0008885739,0.0000496491,0.0001727905,0.00008085001,0.0002412866,0.0000800716,0.00002661489,0.008585319],"genre_scores_gemma":[0.9954509,0.0001585567,0.001245945,0.0002565727,0.0000255514,0.00002852755,0.0007597774,0.00001624592,0.002057966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01886507,"threshold_uncertainty_score":0.6326333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131934289275236,"score_gpt":0.2439259916200457,"score_spread":0.2326066487272933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}