{"id":"W3153454112","doi":"10.1016/j.devcel.2021.04.001","title":"Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease","year":2021,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"National Institute of Environmental Health Sciences; National Institutes of Health; National Cancer Institute; National Human Genome Research Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Drug Abuse","keywords":"Epigenome; Cytotrophoblast; Biology; DNA methylation; Placenta; Transcriptome; Placentation; Histone; Epigenetics; Syncytiotrophoblast; Genetics; Offspring; Pregnancy; Gene; Fetus; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001968717,0.00009972356,0.0001436836,0.0006144655,0.0002182928,0.0005055457,0.0001075552,0.0001786274,0.001849074],"category_scores_gemma":[0.0005254358,0.0001186163,0.0001536593,0.0008150382,0.0001556018,0.0001887811,0.0003138091,0.0002094922,0.0001903008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002302614,"about_ca_system_score_gemma":0.0001627192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002944711,"about_ca_topic_score_gemma":0.002584209,"domain_scores_codex":[0.9999118,0.00002229277,0.000005305036,0.00002991241,0.00001244939,0.0000182708],"domain_scores_gemma":[0.999876,0.00004085037,0.00003364755,0.0000169419,0.00001553207,0.0000170845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002858081,0.00008461301,0.7657443,0.0001637577,0.000238683,0.001100289,0.003301724,0.0003098908,0.1894398,0.0006894527,0.0004789623,0.03559045],"study_design_scores_gemma":[0.000006835387,0.000116673,0.9869668,0.00001476921,0.00006099157,0.000809071,0.0007964504,0.0001424448,0.008249896,0.0002238333,0.002605271,0.000006939632],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954913,0.002132218,0.0003333945,0.00006394036,0.000006869569,0.00000563317,0.0007544207,0.000005850402,0.001206283],"genre_scores_gemma":[0.9971256,0.001106459,0.0001964,0.00003025645,0.000006363342,0.00001137765,0.0004365592,0.000004656276,0.001082256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002944711,"threshold_uncertainty_score":0.00618583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131934289275236,"score_gpt":0.2439259916200457,"score_spread":0.2326066487272933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}