{"id":"W3153542744","doi":"10.1128/aac.00275-21","title":"Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial Treatment","year":2021,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Malaria Research and Control","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Innovative Medicines Initiative; Vetenskapsrådet; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; European Federation of Pharmaceutical Industries and Associations; Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa; European Commission; Research for Patient Benefit Programme; Deutsches Zentrum für Infektionsforschung; Fundação para a Ciência e a Tecnologia; McGill University","keywords":"Malaria; Plasmodium falciparum; Population; Pharmacogenetics; Biology; Artesunate; Artemisinin; Genetics; Pharmacogenomics; Allele; Medicine; Genotype; Gene; Immunology; Environmental health","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002154612,0.0007943852,0.0002077264,0.0008659976,0.0004362855,0.0003235685,0.0002288833,0.0004141983,0.003451679],"category_scores_gemma":[0.0006718606,0.0001201753,0.0002483331,0.0005759562,0.000253098,0.000105804,0.0002431719,0.0002729656,0.0001899317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002013135,"about_ca_system_score_gemma":0.0001677685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008798417,"about_ca_topic_score_gemma":0.01101602,"domain_scores_codex":[0.9998777,0.00003414135,0.00001399603,0.00003517869,0.00001842401,0.00002055888],"domain_scores_gemma":[0.9998243,0.0000571559,0.00005937307,0.00001898917,0.00001754705,0.00002263091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002254831,0.0001198861,0.7308955,0.0002072645,0.0005360886,0.01978391,0.003006652,0.001173582,0.2022697,0.001000403,0.001065229,0.03768701],"study_design_scores_gemma":[0.00005665941,0.000329925,0.9773321,0.00009179266,0.0001898237,0.01126755,0.0008002653,0.001385365,0.005320005,0.0003249937,0.00288134,0.00002018254],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979239,0.000396985,0.0004451671,0.0001498467,0.000008567152,0.00001309303,0.0004128125,0.00001151842,0.0006381287],"genre_scores_gemma":[0.9988086,0.0001719838,0.0003881871,0.00005907831,0.000005683919,0.000005675318,0.0002292443,0.000004804711,0.0003266442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008798417,"threshold_uncertainty_score":0.01749444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0273632403786774,"score_gpt":0.2943816790488161,"score_spread":0.2670184386701387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}