{"id":"W3153569053","doi":"10.1002/jcp.30380","title":"Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production","year":2021,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of British Columbia; McGill University; St. Joseph’s Healthcare Hamilton; McGill University Health Centre","funders":"Institute of Circulatory and Respiratory Health; Natural Sciences and Engineering Research Council of Canada; Institute of Infection and Immunity; Canadian Institutes of Health Research; Taibah University; Canada Foundation for Innovation; National Heart, Lung, and Blood Institute; Boehringer Ingelheim","keywords":"Myofibroblast; Extracellular matrix; Gene knockdown; Pulmonary fibrosis; RNA-binding protein; Idiopathic pulmonary fibrosis; Cytoplasm; Fibroblast; Messenger RNA; Cell biology; Biology; RNA splicing; Fibrosis; Transforming growth factor; Molecular biology; RNA; Cancer research; Lung; Pathology; Cell culture; Medicine; Gene; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001396141,0.0002071475,0.0002195099,0.0002129072,0.0001399769,0.0001692057,0.00007392523,0.0001734513,0.001720354],"category_scores_gemma":[0.0001127654,0.00008281813,0.0002709745,0.0001046122,0.0001211049,0.00009784659,0.0001411749,0.0002697851,0.0005102589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001332501,"about_ca_system_score_gemma":0.0001390659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006624761,"about_ca_topic_score_gemma":0.001419772,"domain_scores_codex":[0.999867,0.00002882798,0.00001206101,0.00002108969,0.00003613615,0.00003494629],"domain_scores_gemma":[0.9999182,0.0000175207,0.00001550529,0.000009598813,0.00001284212,0.00002624301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001326427,0.00005971047,0.0001226468,0.00003810451,0.000004046747,0.00005015272,0.00001543235,0.00001654939,0.9979427,0.00002309604,0.0001166774,0.001478188],"study_design_scores_gemma":[0.00006026305,0.002053446,0.009288686,0.00001180893,0.00002620629,0.0003552536,0.000060069,0.0004650417,0.9825519,0.00004574683,0.005074641,0.00000678689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903811,0.004336961,0.001586071,0.000167041,0.000101302,0.00004639476,0.0002797685,0.0001682822,0.002933077],"genre_scores_gemma":[0.9910613,0.001849653,0.001424157,0.0001096101,0.00003365214,0.00003865666,0.0004967747,0.00002480653,0.00496145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001720354,"threshold_uncertainty_score":0.005755126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007648854333312326,"score_gpt":0.2620527078561479,"score_spread":0.2544038535228356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}