{"id":"W3153569053","doi":"10.1002/jcp.30380","title":"Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production","year":2021,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of British Columbia; McGill University; St. Joseph’s Healthcare Hamilton; McGill University Health Centre","funders":"Institute of Circulatory and Respiratory Health; Natural Sciences and Engineering Research Council of Canada; Institute of Infection and Immunity; Canadian Institutes of Health Research; Taibah University; Canada Foundation for Innovation; National Heart, Lung, and Blood Institute; Boehringer Ingelheim","keywords":"Myofibroblast; Extracellular matrix; Gene knockdown; Pulmonary fibrosis; RNA-binding protein; Idiopathic pulmonary fibrosis; Cytoplasm; Fibroblast; Messenger RNA; Cell biology; Biology; RNA splicing; Fibrosis; Transforming growth factor; Molecular biology; RNA; Cancer research; Lung; Pathology; Cell culture; Medicine; Gene; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001558325,0.0001774522,0.0004661333,0.000164177,0.0001187671,0.00002817933,0.0000709188,0.0001060413,0.0001444306],"category_scores_gemma":[0.0001250286,0.0001517128,0.0001977879,0.0001571796,0.00006514669,0.0001586326,0.00007568361,0.0002076206,0.000007538816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005814537,"about_ca_system_score_gemma":0.0001170248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001172149,"about_ca_topic_score_gemma":0.00000157998,"domain_scores_codex":[0.9986243,0.0001551737,0.00049244,0.0002718274,0.000228802,0.0002274828],"domain_scores_gemma":[0.9988393,0.00002356426,0.0002863846,0.0002053456,0.0004101696,0.0002352973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008455528,0.0003943602,0.001025007,0.0004062605,0.0001326658,0.0001914283,0.0001134188,0.00002989149,0.995632,0.0002317927,0.0007949548,0.0002026769],"study_design_scores_gemma":[0.001938889,0.007844734,0.2292332,0.002656984,0.0007072152,0.00231893,0.0003892917,0.0006005531,0.7505225,0.001179931,0.002095936,0.0005118037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943354,0.003647669,0.0007958708,0.0006740732,0.0002775907,0.0002163452,0.000008080931,0.00001556955,0.00002940219],"genre_scores_gemma":[0.9970829,0.00009535049,0.000736022,0.00005017638,0.001240743,0.000003445639,0.00005043692,0.0000250019,0.0007159229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2451095,"threshold_uncertainty_score":0.6186667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007648854333312326,"score_gpt":0.2620527078561479,"score_spread":0.2544038535228356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}