{"id":"W3153610861","doi":"10.1038/s41398-021-01338-2","title":"Metformin for early comorbid glucose dysregulation and schizophrenia spectrum disorders: a pilot double-blind randomized clinical trial","year":2021,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; St. Michael's Hospital; University of Toronto; Mount Sinai Hospital; Diabetes Canada; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Department of Psychiatry, University of Toronto; University of Toronto; Banting and Best Diabetes Centre, University of Toronto; Physicians' Services Incorporated Foundation","keywords":"Metformin; Prediabetes; Medicine; Internal medicine; Insulin resistance; Type 2 diabetes; Placebo; Body mass index; Endocrinology; Diabetes mellitus; Impaired fasting glucose; Population; Glucose homeostasis; Insulin; Impaired glucose tolerance; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001325041,0.001819166,0.002800856,0.0006598017,0.0006170225,0.001035104,0.000761881,0.001948668,0.007144521],"category_scores_gemma":[0.001525786,0.0007603097,0.001767154,0.0004507715,0.001076791,0.001073761,0.0006068115,0.002011443,0.0009018802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000662032,"about_ca_system_score_gemma":0.001443323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001389834,"about_ca_topic_score_gemma":0.003516439,"domain_scores_codex":[0.9995958,0.0001961259,0.00003345784,0.0000691195,0.00002929127,0.00007618968],"domain_scores_gemma":[0.9991303,0.000193197,0.0001963075,0.00007150431,0.00005534289,0.0003533076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9818886,0.006711004,0.0003581095,0.0004297406,0.0004633176,0.00005318256,0.00003218483,0.0001471528,0.001674627,0.000052301,0.0003671953,0.007822737],"study_design_scores_gemma":[0.9724346,0.02594491,0.0009456057,0.00002001094,0.0001440611,0.00001897942,0.00001250259,0.0001607309,0.0001055066,0.00005216735,0.0001531826,0.000007803539],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883746,0.003168391,0.0004321148,0.000665586,0.0005407525,0.004953871,0.0007734665,0.0001204943,0.0009706363],"genre_scores_gemma":[0.9806669,0.003212363,0.001973687,0.001323144,0.0006225914,0.008328711,0.0008986132,0.00002139863,0.002952519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007144521,"threshold_uncertainty_score":0.02390075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04382105057715407,"score_gpt":0.3430332563235188,"score_spread":0.2992122057463648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}