{"id":"W3153622695","doi":"10.3389/fcell.2021.659397","title":"Pannexin 1 Influences Lineage Specification of Human iPSCs","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Biology; Endoderm; Pannexin; Mesoderm; Ectoderm; Cell biology; Induced pluripotent stem cell; Germ layer; Gene knockout; Lineage (genetic); Paracrine signalling; Cellular differentiation; Genetics; Embryo; Gene; Embryonic stem cell; Embryogenesis; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002710732,0.0001796903,0.0002276842,0.0002537247,0.0001431007,0.0004485387,0.0001949993,0.0003171651,0.001430962],"category_scores_gemma":[0.000210395,0.0001788834,0.0002401746,0.0001461963,0.000124657,0.000188415,0.0002790425,0.0005463837,0.0006088658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000201207,"about_ca_system_score_gemma":0.0001687206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004586835,"about_ca_topic_score_gemma":0.0007450531,"domain_scores_codex":[0.9997322,0.00003477775,0.00004692563,0.00007212566,0.00007374275,0.00004012369],"domain_scores_gemma":[0.9998785,0.00003704963,0.00002427965,0.00001776349,0.00002501219,0.00001731269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005649688,0.000026151,0.0003746681,0.00004317977,0.00000653818,0.0001165943,0.00007098132,0.0002091512,0.995472,0.0002132564,0.0001757929,0.003235276],"study_design_scores_gemma":[0.00001529932,0.0001134852,0.004909291,0.00002582863,0.00003388043,0.0003936934,0.00006126807,0.002393704,0.9784228,0.0001027054,0.01352157,0.000006552285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753763,0.003021638,0.00871023,0.0001982214,0.00009108584,0.0001624647,0.001986924,0.0002017566,0.01025141],"genre_scores_gemma":[0.9814797,0.002003669,0.005336001,0.0001867822,0.00001740887,0.0001244608,0.003080787,0.0001092705,0.007661954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001430962,"threshold_uncertainty_score":0.004787028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120986297873385,"score_gpt":0.2401414560417704,"score_spread":0.2280428262544319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}