{"id":"W3153627057","doi":"10.1038/s41467-021-27345-x","title":"Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"CIHR Skin Research Training Centre; Natural Sciences and Engineering Research Council of Canada; Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering; Government of Canada; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Canadian Institutes of Health Research; Uehara Memorial Foundation; Mother and Child Health Foundation; Sumitomo Foundation","keywords":"Germline; DNA methylation; Gene silencing; Psychological repression; Biology; Genetics; Methylation; Embryo; Gene; DNA; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001056494,0.0001998796,0.0001790718,0.000148597,0.0001553535,0.0003649145,0.0002584232,0.0002095342,0.002829816],"category_scores_gemma":[0.0001232808,0.0002155146,0.0001983638,0.00007744625,0.0002004277,0.0002423728,0.0003789829,0.0005840885,0.00106271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003055079,"about_ca_system_score_gemma":0.0002069362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005050984,"about_ca_topic_score_gemma":0.001127227,"domain_scores_codex":[0.9998585,0.0000129207,0.000009645662,0.00004146818,0.00005415654,0.00002332792],"domain_scores_gemma":[0.9998856,0.0000135641,0.00003465729,0.00001361954,0.00001503293,0.00003753391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004791088,0.000003290752,0.0004214634,0.00003057133,0.000002263455,0.00003836553,0.00001031839,0.00002883756,0.9982973,0.0001751917,0.00003292668,0.0009115849],"study_design_scores_gemma":[0.000005716142,0.00006116466,0.02238308,0.000007183939,0.000005449733,0.0002594524,0.00001668966,0.0003752041,0.9737041,0.00006856922,0.003110277,0.000003125912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736701,0.007983853,0.009551859,0.0001762396,0.00005793161,0.00002684294,0.001302425,0.0002722448,0.006958456],"genre_scores_gemma":[0.9845752,0.001653889,0.00299383,0.00006146821,0.00001403312,0.00002320553,0.001165539,0.00004118419,0.0094717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002829816,"threshold_uncertainty_score":0.009466708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132019917927732,"score_gpt":0.2995488763425543,"score_spread":0.2863468845497811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}