{"id":"W3153638144","doi":"10.1016/j.xcrm.2021.100269","title":"Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome","year":2021,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Weston Brain Institute; University of British Columbia; National Institutes of Health; Michael Smith Health Research BC; Cure Alzheimer's Fund","keywords":"Cytokine storm; Cytokine; Coronavirus disease 2019 (COVID-19); Blockade; Cytokine release syndrome; Interleukin; Interleukin 6; Receptor; Medicine; Cytokine receptor; Storm; Immunology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Internal medicine; Virology; Geography; Disease; Meteorology; Outbreak","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004439919,0.0003047023,0.0009761374,0.0002521201,0.0001626367,0.00002019705,0.000251126,0.0001573808,0.002959506],"category_scores_gemma":[0.08650309,0.0001855661,0.0001868312,0.001065254,0.0006220252,0.00007154299,0.0003147021,0.001001309,0.00007672598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000651054,"about_ca_system_score_gemma":0.001727712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009648509,"about_ca_topic_score_gemma":0.0002773695,"domain_scores_codex":[0.995442,0.0002695667,0.001271461,0.0008434367,0.00150775,0.0006657479],"domain_scores_gemma":[0.9916954,0.005403519,0.0003208892,0.001508003,0.0003566994,0.0007154912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006079855,0.002097643,0.1939468,0.004275882,0.0003028132,0.2183741,0.009393821,0.00006330651,0.02663947,0.0001678507,0.5399764,0.004153894],"study_design_scores_gemma":[0.002968347,0.001083408,0.01590932,0.0004800838,0.0001515031,0.002033851,0.002108651,0.00003333829,0.0009484444,0.0005086281,0.9735498,0.0002245834],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5760283,0.006858137,0.0009671246,0.3870064,0.003116569,0.002314796,0.000009815401,0.0002756566,0.02342315],"genre_scores_gemma":[0.9480031,0.001791207,0.0001577077,0.03096034,0.0005277346,0.0001135244,0.0001088222,0.00003919229,0.01829839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4335734,"threshold_uncertainty_score":0.9979519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07070862201863262,"score_gpt":0.4068116618031676,"score_spread":0.336103039784535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}