{"id":"W3153730804","doi":"10.1002/adtp.202100022","title":"Targeting Signaling Pathways of Hyaluronic Acid and Integrin Receptors by Synergistic Combination Nanocomposites Inhibits Systemic Metastases and Primary Triple Negative Breast Cancer","year":2021,"lang":"en","type":"article","venue":"Advanced Therapeutics","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cancer research; Triple-negative breast cancer; Doxorubicin; Hyaluronic acid; Metastasis; Integrin; Nanomedicine; Chemistry; In vitro; Cancer cell; Pharmacology; Cancer; Receptor; Breast cancer; Medicine; Materials science; Chemotherapy; Biochemistry; Internal medicine; Nanoparticle; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001679795,0.0001801371,0.0002472936,0.00004106195,0.0001066857,0.0000283696,0.00008951227,0.00009427245,0.000007603442],"category_scores_gemma":[0.00003933596,0.0001671025,0.0000393582,0.000150167,0.0001432401,0.00001608235,0.0001172268,0.0001383165,2.094346e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004240649,"about_ca_system_score_gemma":0.0001368791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002940173,"about_ca_topic_score_gemma":0.00001080726,"domain_scores_codex":[0.9988186,0.000164528,0.0002686582,0.0003522394,0.0001593132,0.0002365999],"domain_scores_gemma":[0.9993222,0.00006134322,0.0001429444,0.0001520966,0.0002556918,0.00006565945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001519475,0.00006357836,0.0004903013,0.0001552698,0.000124459,0.000002216156,0.0001010199,0.0001330059,0.9630982,0.0000828253,0.000009161648,0.03558799],"study_design_scores_gemma":[0.001091028,0.00022695,0.0001104498,0.0001521666,0.00004623499,0.00002866175,0.0003905029,0.0002577571,0.9968203,0.0001384373,0.0005491315,0.0001883891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9561591,0.04050296,0.002626289,0.00007778679,0.00007110008,0.0002744594,0.0002577694,0.000009865103,0.00002064737],"genre_scores_gemma":[0.9901097,0.00783864,0.001543659,0.00009668143,0.00002720694,0.00005184613,0.0002251735,0.00002622892,0.00008079592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0353996,"threshold_uncertainty_score":0.6814243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094146320056878,"score_gpt":0.2565569528914055,"score_spread":0.2456154896908367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}