{"id":"W3153743655","doi":"10.1016/j.ekir.2021.03.455","title":"POS-432 DELETION OF THE POLYCYSTIN-1 COILED-COIL MOTIF LEADS TO A SEVERE FUNCTIONAL HYPOMORPHIC ADPKD ALLELE IN MICE: INSIGHTS INTO INTRACELLULAR MECHANISMS","year":2021,"lang":"en","type":"article","venue":"Kidney International Reports","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"PKD1; Autosomal dominant polycystic kidney disease; Allele; Medicine; Polycystic kidney disease; Gene; Genetics; Cell biology; Kidney; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001707575,0.0006508029,0.0003364003,0.000671305,0.0002716191,0.0003952218,0.0003348438,0.0007754992,0.004128236],"category_scores_gemma":[0.0001436268,0.0003791193,0.0003522819,0.000243431,0.0005246159,0.0002528331,0.0003970215,0.001045049,0.001119328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236167,"about_ca_system_score_gemma":0.0002507656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000531632,"about_ca_topic_score_gemma":0.0005100209,"domain_scores_codex":[0.9997311,0.00004136265,0.00004143917,0.00007021144,0.00007741946,0.00003831065],"domain_scores_gemma":[0.9996873,0.00005061744,0.00009442903,0.00001815489,0.00001683462,0.0001326981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00013952,0.0000511097,0.0001832534,0.00002926271,0.00001016738,0.0005506576,0.00001900465,0.000111825,0.9979081,0.0002939166,0.00007900436,0.0006242842],"study_design_scores_gemma":[0.0001374037,0.0004401323,0.01184597,0.00003966793,0.00006484755,0.006520018,0.00008258547,0.002691169,0.9707896,0.0004717951,0.006889484,0.000027437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838855,0.0009026565,0.008736699,0.0003751042,0.00009727696,0.00006347003,0.002148801,0.0003323734,0.003458075],"genre_scores_gemma":[0.9835712,0.0009959288,0.004653248,0.0001794238,0.00003477211,0.00008563409,0.002071376,0.0002473914,0.008161037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004128236,"threshold_uncertainty_score":0.01381034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005785009683720515,"score_gpt":0.2129496809057719,"score_spread":0.2071646712220514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}