{"id":"W3153805419","doi":"10.14288/1.0396548","title":"Premature termination codon readthrough restores progranulin expression in preclinical models of frontotemporal dementia and neuronal ceroid lipofuscinosis","year":2021,"lang":"en","type":"article","venue":"cIRcle (University of British Columbia)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Frontotemporal dementia; Neuronal ceroid lipofuscinosis; Dementia; Medicine; Neuroscience; Genetics; Biology; Gene; Psychology; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005258502,0.0006189346,0.0005361642,0.0006648603,0.0002570099,0.0004184306,0.0005722413,0.0008129424,0.00148218],"category_scores_gemma":[0.0001668476,0.0002571435,0.0004472986,0.0002738514,0.0003396729,0.0003091799,0.0002215501,0.001493682,0.0004656279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000444138,"about_ca_system_score_gemma":0.0004804627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267758,"about_ca_topic_score_gemma":0.002008227,"domain_scores_codex":[0.9996783,0.00004965178,0.00003744283,0.00004805207,0.0001100084,0.00007659756],"domain_scores_gemma":[0.9998275,0.00002376941,0.00004371547,0.00001666447,0.00002417114,0.00006410206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000550407,0.0005792924,0.0001020105,0.0001347991,0.00002115421,0.0002068275,0.00004640411,0.0002133608,0.9942661,0.0002496311,0.0002674508,0.003362556],"study_design_scores_gemma":[0.0001753152,0.006106176,0.0014893,0.00002203708,0.00007050514,0.0003757853,0.0000527833,0.0009023027,0.9863554,0.0001107562,0.004327236,0.00001233032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877808,0.002578879,0.00334094,0.0003907519,0.0001408468,0.000216148,0.001397668,0.000419302,0.00373469],"genre_scores_gemma":[0.9833156,0.003201804,0.004318766,0.000226562,0.00002887071,0.0003059773,0.001816761,0.00005365265,0.006731999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00148218,"threshold_uncertainty_score":0.004958391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03102240345214266,"score_gpt":0.2567881312468769,"score_spread":0.2257657277947342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}