{"id":"W3153813300","doi":"10.1053/j.gastro.2021.03.065","title":"Challenges and Opportunities in IBD Clinical Trial Design","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Pharmaceuticals; National Institute of Diabetes and Digestive and Kidney Diseases; Cumming School of Medicine, University of Calgary; Perelman School of Medicine, University of Pennsylvania; University of California, San Diego; Humanitas Research Hospital; Chinese University of Hong Kong; University of Oxford; Cedars-Sinai Medical Center; Barts Health NHS Trust; All-India Institute of Medical Sciences; KU Leuven; Harvard School of Dental Medicine; University of Miami; Icahn School of Medicine at Mount Sinai; Pfizer; Northwestern University; Universitaire Ziekenhuizen Leuven, KU Leuven; Dartmouth College; Bristol-Myers Squibb; British Heart Foundation; Takeda Pharmaceutical Company; AbbVie; University of Pennsylvania; Roche; Mayo Clinic; Boehringer Ingelheim; Amgen; Tillotts Pharma; Amsterdam University Medical Centers; EA Pharma Co., Ltd.; Gilead Sciences","keywords":"Clinical trial; Medicine; Scopus; Inflammatory bowel disease; Clinical study design; Family medicine; Alternative medicine; Disease; MEDLINE; Internal medicine; Pathology; Political science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.6503046,0.001490269,0.008730805,0.00563824,0.00559698,0.02728206,0.0102533,0.01386872,0.03621009],"category_scores_gemma":[0.8501731,0.00286212,0.003712126,0.005296787,0.01272572,0.01382318,0.01089373,0.0205934,0.01243053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006481019,"about_ca_system_score_gemma":0.0613945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003411699,"about_ca_topic_score_gemma":0.00571643,"domain_scores_codex":[0.3299825,0.5734459,0.04184822,0.01049483,0.04019929,0.004029261],"domain_scores_gemma":[0.0576365,0.7514223,0.02585644,0.03887817,0.1085366,0.01766994],"domain_codex":"methods","domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003677584,0.0004189765,0.004386189,0.01437214,0.001624393,0.000591461,0.002933269,0.001712288,0.0006898065,0.03677038,0.3703019,0.5625215],"study_design_scores_gemma":[0.006824872,0.002008635,0.00728436,0.02713588,0.002380485,0.001055021,0.003827647,0.01117762,0.001325023,0.2770798,0.6592864,0.0006142115],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.004346142,0.07381674,0.06185812,0.7249456,0.1023034,0.006906678,0.001320451,0.0008158881,0.02368692],"genre_scores_gemma":[0.1261842,0.06209034,0.3481783,0.2268432,0.1901627,0.02458672,0.001912369,0.002013863,0.01802848],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.6503046,"threshold_uncertainty_score":0.4312367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1249780573605359,"score_gpt":0.3235925913911219,"score_spread":0.198614534030586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}