{"id":"W3153987633","doi":"10.1186/s13059-021-02323-0","title":"Comparative regulomics supports pervasive selection on gene dosage following whole genome duplication","year":2021,"lang":"en","type":"article","venue":"Genome biology","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Biotechnology and Biological Sciences Research Council; Norges Miljø- og Biovitenskapelige Universitet; Norges Forskningsråd","keywords":"Biology; Gene duplication; Genome; Transposable element; Genome evolution; Gene; Genetics; Gene dosage; Copy-number variation; Negative selection; Evolutionary biology; Functional divergence; Gene expression; Gene family","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033436,0.0001426716,0.0002233022,0.00001511452,0.0003064952,0.0000367005,0.0001305712,0.0001405156,0.0005677521],"category_scores_gemma":[0.0000228539,0.00007004751,0.0001262711,0.0003345317,0.00003390061,0.00004348556,0.00006461804,0.00009908035,0.0002173548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006769769,"about_ca_system_score_gemma":0.00003527516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004345274,"about_ca_topic_score_gemma":0.0003867603,"domain_scores_codex":[0.9988737,0.000118093,0.0002145919,0.0004450777,0.00007601867,0.0002725834],"domain_scores_gemma":[0.9995451,0.00009142554,0.00009374361,0.00008111458,0.0001064873,0.00008210298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001017682,0.000073237,0.00220003,0.000001092266,0.00003629607,0.000004758437,0.0001690386,0.00007119001,0.9956357,0.0004833924,0.00002152728,0.001293534],"study_design_scores_gemma":[0.0003510476,0.0007670516,0.7408083,0.000006133322,0.00005093415,0.00007134163,0.0003784283,0.0001051379,0.06361404,0.003408968,0.1899948,0.0004438484],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961725,0.000322977,0.00006939473,0.001534333,0.0001938702,0.0001957462,0.0001855912,0.00005164444,0.001273901],"genre_scores_gemma":[0.9954136,0.00004956093,0.0003616485,0.0003931468,0.0004196975,0.00003863981,0.002390101,0.000001277333,0.0009323398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9320217,"threshold_uncertainty_score":0.6216488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02443797718383469,"score_gpt":0.2479232046304818,"score_spread":0.2234852274466471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}