{"id":"W3154015170","doi":"10.1128/mbio.00226-21","title":"<i>In Vivo</i> Antigen Expression Regulates CD4 T Cell Differentiation and Vaccine Efficacy against Mycobacterium tuberculosis Infection","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; Statens Serum Institut; Canadian Institutes of Health Research; McGill University Health Centre; National Institutes of Health; H. Lundbeck A/S; Lundbeckfonden; Government of Canada; McGill University; Sundhed og Sygdom, Det Frie Forskningsråd","keywords":"Mycobacterium tuberculosis; Antigen; Tuberculosis; In vivo; Immunology; Virology; Biology; Microbiology; Tuberculosis vaccines; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002008369,0.0001378599,0.0001863157,0.0001192265,0.0001095568,0.0004572976,0.0001201665,0.0002572302,0.001298179],"category_scores_gemma":[0.0002440096,0.00007172964,0.0001061755,0.00009340173,0.00020037,0.0001915979,0.0001114179,0.000728789,0.000371301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000164725,"about_ca_system_score_gemma":0.0001330298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002068254,"about_ca_topic_score_gemma":0.0003309005,"domain_scores_codex":[0.9998201,0.00006021568,0.00001697308,0.00002747656,0.00002144566,0.00005387619],"domain_scores_gemma":[0.9998682,0.0000344965,0.00002984546,0.00001387069,0.00001643895,0.00003717928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004475434,0.0001090225,0.0008343146,0.00002655921,0.000002787545,0.00001846079,0.00001892581,0.00009236275,0.9966056,0.00006705655,0.00008367421,0.00169371],"study_design_scores_gemma":[0.00006822398,0.001804294,0.01992433,0.00001742562,0.0000315888,0.0001728459,0.0001111333,0.001638686,0.973359,0.000138683,0.002727236,0.000006508634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970964,0.0008462948,0.0006681091,0.0001134428,0.00002873856,0.00001054846,0.0001126965,0.00002370329,0.001100125],"genre_scores_gemma":[0.9983678,0.0002459046,0.0003494693,0.00007643159,0.00001368938,0.00001304397,0.0001279177,0.000009691929,0.0007960831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001298179,"threshold_uncertainty_score":0.004342854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215835128712193,"score_gpt":0.2765279945600006,"score_spread":0.2643696432728787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}