{"id":"W3154015170","doi":"10.1128/mbio.00226-21","title":"<i>In Vivo</i> Antigen Expression Regulates CD4 T Cell Differentiation and Vaccine Efficacy against Mycobacterium tuberculosis Infection","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; Statens Serum Institut; Canadian Institutes of Health Research; McGill University Health Centre; National Institutes of Health; H. Lundbeck A/S; Lundbeckfonden; Government of Canada; McGill University; Sundhed og Sygdom, Det Frie Forskningsråd","keywords":"Mycobacterium tuberculosis; Antigen; Tuberculosis; In vivo; Immunology; Virology; Biology; Microbiology; Tuberculosis vaccines; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002210603,0.0001580667,0.0003596026,0.0001465098,0.00007470581,0.00002590857,0.00003329669,0.0001777033,0.0002977994],"category_scores_gemma":[0.0002894941,0.0001337055,0.00008145214,0.0002451799,0.00002393063,0.0001378379,0.00007412604,0.0002293038,0.00002941781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006681786,"about_ca_system_score_gemma":0.00003132634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001360077,"about_ca_topic_score_gemma":0.00008304772,"domain_scores_codex":[0.9985952,0.0002061597,0.0003083931,0.0003916096,0.0001521794,0.0003464905],"domain_scores_gemma":[0.9992663,0.0001387957,0.00006042839,0.0002780839,0.00008035103,0.000176001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001024447,0.0002156789,0.3000308,0.0001088839,0.00001880577,0.00003225412,0.00007754775,0.000005334713,0.6925465,0.000006601338,0.005901779,0.0009532667],"study_design_scores_gemma":[0.001231062,0.00007916398,0.5364912,0.00009828738,0.00001732354,0.00001925032,0.00001111171,0.0002274701,0.4565903,0.00003291685,0.005117933,0.00008400883],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941166,0.0007128713,0.0000325312,0.00326441,0.0001858173,0.0002287769,0.000007753461,0.00004464729,0.00140661],"genre_scores_gemma":[0.9931144,0.00482658,0.0001530678,0.000903261,0.0001957812,0.00001662443,0.0001408769,0.00002017988,0.0006292276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2364604,"threshold_uncertainty_score":0.5452354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215835128712193,"score_gpt":0.2765279945600006,"score_spread":0.2643696432728787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}