{"id":"W3154017310","doi":"10.3390/ijms22084134","title":"The Multifaceted Roles of Ku70/80","year":2021,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Association Neurofibromatoses et Recklinghause; Agence Nationale de la Recherche; CNIB","keywords":"Ku70; Biology; DNA repair; DNA ligase; DNA; Non-homologous end joining; Homologous recombination; Ku80; Nuclease; Telomere; DNA damage; Cell biology; Genome instability; DNA repair protein XRCC4; Effector; Genetics; Computational biology; Nucleotide excision repair; Gene; DNA-binding protein; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000945378,0.0001819396,0.0004646395,0.0001325761,0.00006394005,0.0001389953,0.001779932,0.0001423803,0.000007495864],"category_scores_gemma":[0.0005509486,0.000112524,0.0007015974,0.0001600267,0.0002679505,0.000008001452,0.0002899841,0.0001651213,0.000001530961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002485676,"about_ca_system_score_gemma":0.0007228953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001463581,"about_ca_topic_score_gemma":0.000003876044,"domain_scores_codex":[0.997963,0.0002362507,0.000563889,0.0002260359,0.0008576691,0.0001531543],"domain_scores_gemma":[0.997866,0.00006734479,0.001082709,0.0002219118,0.0007058189,0.00005619512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000009772475,0.00005545394,0.000003017902,0.0001121648,0.0008102133,0.0001157238,0.00002458179,0.00004789333,0.02623746,0.0009376445,0.0004029656,0.9712431],"study_design_scores_gemma":[0.0001377115,0.0001905395,6.36309e-7,0.001607506,0.0001222553,0.0005339237,0.0001342746,0.00001255302,0.0376897,0.00009173469,0.959339,0.0001401908],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001145267,0.9962694,0.001101644,0.0001841571,0.001014415,0.00008854589,0.0000133416,0.000001789205,0.0001814313],"genre_scores_gemma":[0.002545444,0.9948994,0.002120799,0.00004130833,0.0002042863,0.000004096265,0.00001287325,0.00001501957,0.0001567556],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9711029,"threshold_uncertainty_score":0.4588596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02446100948429655,"score_gpt":0.3438555542855378,"score_spread":0.3193945448012412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}