{"id":"W3154017310","doi":"10.3390/ijms22084134","title":"The Multifaceted Roles of Ku70/80","year":2021,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Association Neurofibromatoses et Recklinghause; Agence Nationale de la Recherche; CNIB","keywords":"Ku70; Biology; DNA repair; DNA ligase; DNA; Non-homologous end joining; Homologous recombination; Ku80; Nuclease; Telomere; DNA damage; Cell biology; Genome instability; DNA repair protein XRCC4; Effector; Genetics; Computational biology; Nucleotide excision repair; Gene; DNA-binding protein; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003859707,0.0008213897,0.0008871391,0.001806859,0.0002670641,0.0009115474,0.0007884015,0.0008837289,0.002450333],"category_scores_gemma":[0.0004099979,0.0002615721,0.0003189027,0.001727535,0.0004503201,0.001392199,0.0006024032,0.001485995,0.001796678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005779656,"about_ca_system_score_gemma":0.0009353649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006621343,"about_ca_topic_score_gemma":0.0009726107,"domain_scores_codex":[0.9998798,0.00001557369,0.00001771617,0.00002722867,0.00004396809,0.00001556026],"domain_scores_gemma":[0.9998405,0.00006151348,0.00002228874,0.000005688327,0.00004808962,0.00002200219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008295313,0.00004088362,0.0001798761,0.01239291,0.00005559716,0.0001641877,0.00005879387,0.0003533337,0.003216208,0.005166369,0.02089156,0.9573973],"study_design_scores_gemma":[0.000009112325,0.00007072724,0.0007096027,0.001627362,0.00005500867,0.0009005395,0.00003869288,0.00005933364,0.0008296625,0.002031202,0.9936535,0.00001516083],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001348933,0.9985015,0.0001046622,0.0002186928,0.0001298181,0.000002371503,0.00001270622,0.000006879436,0.0008884489],"genre_scores_gemma":[0.0006096682,0.9984962,0.0001169968,0.0001047657,0.0001183869,0.000003661976,0.00002270909,0.00000117126,0.0005263784],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002450333,"threshold_uncertainty_score":0.008197248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02446100948429655,"score_gpt":0.3438555542855378,"score_spread":0.3193945448012412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}