{"id":"W3154042781","doi":"10.3390/antibiotics10050507","title":"Aminoglycosides in the Intensive Care Unit: What Is New in Population PK Modeling?","year":2021,"lang":"en","type":"review","venue":"Antibiotics","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre Hospitalier Universitaire Sainte-Justine; Institut universitaire de cardiologie et de pneumologie de Québec; Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Réseau Québécois de Recherche sur les Médicaments","keywords":"Tobramycin; Amikacin; Aminoglycoside; Medicine; Dosing; Gentamicin; Population; Pharmacokinetics; Regimen; Intensive care medicine; Intensive care unit; Volume of distribution; NONMEM; Pharmacology; Internal medicine; Antibiotics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002043012,0.0004655058,0.001579707,0.0003917282,0.0000478911,0.0001576391,0.0002861827,0.0004474467,0.00002941547],"category_scores_gemma":[0.0001847785,0.0003343706,0.0003856812,0.0009173761,0.00004292872,0.0001029178,0.0001281072,0.001006946,0.00003704615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001258431,"about_ca_system_score_gemma":0.0003925556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004685309,"about_ca_topic_score_gemma":0.0001403183,"domain_scores_codex":[0.9976994,0.0001553509,0.0008552775,0.0005157652,0.0003702918,0.0004039583],"domain_scores_gemma":[0.9985152,0.0001456096,0.0002021321,0.0006410811,0.0003856006,0.0001103868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001142323,0.0001170958,0.001487396,0.008995605,0.0001133375,0.0005843877,0.003227568,0.000153399,0.000001072485,0.0002592284,0.000727163,0.9843223],"study_design_scores_gemma":[0.00224983,0.0002730729,0.0008811526,0.1633149,0.003922289,0.0004450727,0.02188858,0.009785361,0.00003534184,0.0001022133,0.7957461,0.001356085],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002530673,0.9952949,0.00005595991,0.0005453842,0.0004529859,0.0009279922,0.00001566539,0.00001832639,0.0001581453],"genre_scores_gemma":[0.02735351,0.9689772,0.0002460166,0.001956972,0.0003345969,2.785291e-7,0.0008979241,0.00007807303,0.0001554049],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9829662,"threshold_uncertainty_score":0.9999108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1143147788376021,"score_gpt":0.4087028453831149,"score_spread":0.2943880665455128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}