{"id":"W3154042781","doi":"10.3390/antibiotics10050507","title":"Aminoglycosides in the Intensive Care Unit: What Is New in Population PK Modeling?","year":2021,"lang":"en","type":"review","venue":"Antibiotics","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre Hospitalier Universitaire Sainte-Justine; Institut universitaire de cardiologie et de pneumologie de Québec; Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Réseau Québécois de Recherche sur les Médicaments","keywords":"Tobramycin; Amikacin; Aminoglycoside; Medicine; Dosing; Gentamicin; Population; Pharmacokinetics; Regimen; Intensive care medicine; Intensive care unit; Volume of distribution; NONMEM; Pharmacology; Internal medicine; Antibiotics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01706506,0.00130761,0.005293884,0.003409412,0.0003684942,0.005425878,0.003910304,0.003623394,0.002347647],"category_scores_gemma":[0.04689499,0.0007976126,0.003256912,0.005812446,0.00186764,0.009557892,0.001641967,0.003817697,0.0009058405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002019118,"about_ca_system_score_gemma":0.005655542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003337129,"about_ca_topic_score_gemma":0.003406411,"domain_scores_codex":[0.9935997,0.003655363,0.0008543731,0.000723262,0.001016763,0.000150634],"domain_scores_gemma":[0.9429056,0.04860608,0.002825505,0.001173089,0.003903468,0.0005863514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004375966,0.0001056248,0.005505176,0.08246856,0.002244919,0.0007219673,0.0008992328,0.02116427,0.0006513002,0.0228273,0.02263811,0.8403359],"study_design_scores_gemma":[0.0003555237,0.001110215,0.01076477,0.1802474,0.004369441,0.004162177,0.002798403,0.05636115,0.001092173,0.20147,0.536691,0.000577899],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00188434,0.9550307,0.01948636,0.02119228,0.0009649386,0.0000458598,0.0002306129,0.0001065558,0.001058339],"genre_scores_gemma":[0.01601521,0.9695963,0.009479655,0.002565774,0.00195235,0.00007006754,0.0001662121,0.00003581537,0.0001185879],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01706506,"threshold_uncertainty_score":0.09024978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1143147788376021,"score_gpt":0.4087028453831149,"score_spread":0.2943880665455128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}