{"id":"W3154101342","doi":"10.3390/metabo11040239","title":"Specialized Metabolites from Ribosome Engineered Strains of Streptomyces clavuligerus","year":2021,"lang":"en","type":"article","venue":"Metabolites","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Streptomyces clavuligerus; Streptomyces; In silico; Metabolic engineering; Metabolomics; Computational biology; Biology; Metabolite; Gene; Biochemistry; Secondary metabolite; Biotechnology; Chemistry; Genetics; Bioinformatics; Actinomycetales; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002021274,0.0002881949,0.001021347,0.0001498835,0.00005139761,0.00004379543,0.0001565295,0.0001519612,0.004323653],"category_scores_gemma":[0.001053262,0.0002189881,0.0003526803,0.0005862336,0.0001147872,0.0001287168,0.0000768891,0.0002206789,0.00005008828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001777685,"about_ca_system_score_gemma":0.0001669325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001415375,"about_ca_topic_score_gemma":0.0000174188,"domain_scores_codex":[0.9980729,0.0001111388,0.0005856741,0.000512246,0.0003597579,0.00035831],"domain_scores_gemma":[0.9984911,0.0001701945,0.0001647185,0.0006029668,0.000399566,0.0001714553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007368347,0.0002222749,0.002043241,0.00008180091,0.0004540074,0.00004073584,0.0001878538,8.175512e-7,0.9841413,0.002550396,0.0007521782,0.009451687],"study_design_scores_gemma":[0.000897422,0.00002568847,0.03941658,0.0000632728,0.0005384059,0.00001268648,0.0001585659,0.000006739247,0.8582324,0.0005958419,0.09985412,0.0001982394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9496399,0.04553847,0.00001937952,0.001568339,0.0004837165,0.0002371033,0.0007131905,0.00008959185,0.001710371],"genre_scores_gemma":[0.9819958,0.001630042,0.01224516,0.0003263259,0.001250703,0.000001766888,0.0003295142,0.00003396125,0.002186699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1259089,"threshold_uncertainty_score":0.9965865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174552158338957,"score_gpt":0.2551229667017851,"score_spread":0.2376677508678894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}