{"id":"W3154101342","doi":"10.3390/metabo11040239","title":"Specialized Metabolites from Ribosome Engineered Strains of Streptomyces clavuligerus","year":2021,"lang":"en","type":"article","venue":"Metabolites","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Streptomyces clavuligerus; Streptomyces; In silico; Metabolic engineering; Metabolomics; Computational biology; Biology; Metabolite; Gene; Biochemistry; Secondary metabolite; Biotechnology; Chemistry; Genetics; Bioinformatics; Actinomycetales; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002217381,0.0008480355,0.0004884404,0.0005021139,0.0001789403,0.0004432161,0.0002261263,0.0002982756,0.0005433316],"category_scores_gemma":[0.0002383169,0.0001477793,0.0004079618,0.0006103701,0.0001944298,0.0001949657,0.0004773417,0.0004694281,0.0003288356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003154931,"about_ca_system_score_gemma":0.0003005963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007499,"about_ca_topic_score_gemma":0.00146839,"domain_scores_codex":[0.9997531,0.00004235506,0.0000333453,0.00005720493,0.00007518916,0.00003883469],"domain_scores_gemma":[0.9998484,0.00002839665,0.00005393514,0.0000221147,0.00001832464,0.00002872437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004726633,0.00001944804,0.0001259129,0.00002575901,0.000003272768,0.00004672235,0.000008283243,0.000107335,0.9987199,0.00003132031,0.00001229608,0.0008526517],"study_design_scores_gemma":[0.00001347065,0.0002514422,0.004257663,0.000007791771,0.00002543065,0.000160271,0.00003889701,0.001251702,0.9923347,0.00005827972,0.001590271,0.00001006966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881083,0.0007851779,0.007522021,0.0001128606,0.00004913886,0.00008593056,0.001475505,0.0003305021,0.001530615],"genre_scores_gemma":[0.9704156,0.00081022,0.01836043,0.00007215244,0.00001737299,0.0000883398,0.006846857,0.0001953867,0.003193752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001007499,"threshold_uncertainty_score":0.002289057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174552158338957,"score_gpt":0.2551229667017851,"score_spread":0.2376677508678894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}