{"id":"W3154148282","doi":"10.3390/cells10040960","title":"Tissue-Resident and Recruited Macrophages in Primary Tumor and Metastatic Microenvironments: Potential Targets in Cancer Therapy","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Macrophage; Metastasis; Cancer; Immunotherapy; Cancer research; Biology; Tumor microenvironment; Immune system; Immunity; Immunology; Innate immune system; Tumor progression; Primary tumor; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002825776,0.0005086726,0.00179003,0.0002667516,0.00005791049,0.0000322493,0.0002347504,0.0003036741,0.001499232],"category_scores_gemma":[0.00001059923,0.0004497432,0.0001124565,0.0001908143,0.0002970604,0.00006563748,0.0002722402,0.0007130312,0.00008086656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000302004,"about_ca_system_score_gemma":0.0001989558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003571896,"about_ca_topic_score_gemma":0.00003717569,"domain_scores_codex":[0.9972442,0.0007527467,0.0007279672,0.0007294149,0.00004982808,0.0004957819],"domain_scores_gemma":[0.9991465,0.0001586521,0.0003016905,0.0003531849,0.00001416445,0.00002585133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004575399,0.0001769071,0.00003680258,0.004782303,0.0004336601,0.0005803537,0.0003575961,0.000002910319,0.0628006,0.000001484597,0.002425548,0.9283561],"study_design_scores_gemma":[0.00151487,0.00006241063,0.0002927692,0.004386019,0.0002460256,0.0001508201,0.00005280553,1.154923e-7,0.01807124,0.000008694562,0.9747444,0.00046982],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004100958,0.9934677,0.000003208795,0.00002191503,0.001055287,0.001163605,0.0001238089,0.00001162459,0.00005184824],"genre_scores_gemma":[0.000149656,0.9945138,0.000109469,0.000175343,0.00002164453,0.0002853699,0.0002719098,0.00007128826,0.004401552],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9723189,"threshold_uncertainty_score":0.9997954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02843483102285606,"score_gpt":0.309873682771065,"score_spread":0.2814388517482089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}