{"id":"W3154166937","doi":"10.21203/rs.3.rs-30934/v2","title":"COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms","year":2020,"lang":"en","type":"preprint","venue":"","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; U.S. Air Force; Defense Advanced Research Projects Agency; Defense Threat Reduction Agency; Advanced Research Projects Agency; U.S. Department of Defense","keywords":"Famotidine; Histamine; Mast cell; Coronavirus disease 2019 (COVID-19); Dysfunctional family; Pandemic; Mechanism (biology); Immunology; Medicine; Disease; Pharmacology; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007799237,0.0005076008,0.0004510057,0.0003911656,0.0003260252,0.001096033,0.0004145403,0.001130078,0.006771448],"category_scores_gemma":[0.0003154637,0.0001638255,0.0003246815,0.0002629423,0.0005549206,0.000887901,0.0004354273,0.0005803434,0.001546958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006227319,"about_ca_system_score_gemma":0.0004212658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004334674,"about_ca_topic_score_gemma":0.000412806,"domain_scores_codex":[0.9998127,0.00003768079,0.00001712371,0.0000351,0.0000536811,0.00004380831],"domain_scores_gemma":[0.9998149,0.00002889005,0.0000606187,0.00001351874,0.00002509439,0.0000568801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.003645067,0.0003775025,0.006255294,0.002404022,0.0001178031,0.003760566,0.0001968923,0.0004480729,0.8444395,0.00985939,0.009149477,0.1193464],"study_design_scores_gemma":[0.000518881,0.005796842,0.1032106,0.0007226684,0.000267707,0.01483853,0.000657321,0.004198541,0.7047706,0.01352406,0.1514112,0.00008311737],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5884388,0.3008333,0.02526046,0.02210374,0.003388457,0.0004604132,0.002022211,0.001172432,0.05632027],"genre_scores_gemma":[0.9137095,0.04671265,0.006441854,0.002361655,0.001618806,0.0001152192,0.000996558,0.00005643627,0.02798728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006771448,"threshold_uncertainty_score":0.02265275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02211699869457823,"score_gpt":0.2367699138907653,"score_spread":0.2146529151961871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}